Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice

J Allergy Clin Immunol. 2018 Oct;142(4):1349-1352.e16. doi: 10.1016/j.jaci.2018.05.031. Epub 2018 Jun 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / adverse effects*
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Pruritus / chemically induced*
  • Pruritus / drug therapy
  • Pruritus / immunology*
  • Receptor, Serotonin, 5-HT2B / immunology*
  • Serotonin / adverse effects
  • Serotonin and Noradrenaline Reuptake Inhibitors / adverse effects*
  • Skin / metabolism
  • TRPC Cation Channels / genetics
  • TRPC Cation Channels / immunology*

Substances

  • Antidepressive Agents
  • Receptor, Serotonin, 5-HT2B
  • Serotonin and Noradrenaline Reuptake Inhibitors
  • TRPC Cation Channels
  • TRPC4 ion channel
  • Serotonin