Metastases to the parotid gland - A review of the clinicopathological evolution, molecular mechanisms and management

James Badlani; Ruta Gupta; Joel Smith; Bruce Ashford; Sydney Ch'ng; Michael Veness; Jonathan Clark

doi:10.1016/j.suronc.2017.11.007

Metastases to the parotid gland - A review of the clinicopathological evolution, molecular mechanisms and management

Surg Oncol. 2018 Mar;27(1):44-53. doi: 10.1016/j.suronc.2017.11.007. Epub 2017 Dec 2.

Authors

James Badlani¹, Ruta Gupta², Joel Smith³, Bruce Ashford⁴, Sydney Ch'ng³, Michael Veness⁵, Jonathan Clark⁶

Affiliations

¹ Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Department of Oral and Maxillofacial Surgery, Gold Coast University Hospital, Southport, Queensland, Australia. Electronic address: jsbadlani@yahoo.com.
² Department of Pathology, Royal Prince Alfred Hospital, New South Wales, Australia; Central Clinical School, University of Sydney, New south Wales, Australia.
³ Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
⁴ Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Department of Surgery, Wollongong Hospital, Wollongong, New South Wales, Australia.
⁵ Central Clinical School, University of Sydney, New south Wales, Australia; Department of Radiation Oncology, Westmead Hospital, Westmead, New South Wales, Australia.
⁶ Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Central Clinical School, University of Sydney, New south Wales, Australia.

PMID: 29549903
DOI: 10.1016/j.suronc.2017.11.007

Abstract

Metastases to the parotid gland are the commonest cause of parotid malignancies in many regions of the world including Australia. The most common etiology of these metastases is head and neck cutaneous squamous cell carcinoma (HNcSCC) followed by melanoma of the head and neck. This article focuses on the management of the aforementioned pathologies including Merkel cell carcinoma (MCC).

Keywords: Head and neck neoplasms; Melanoma; Merkel cell carcinoma; Parotid neoplasms; Squamous cell carcinoma.

Publication types

Review

MeSH terms

Disease Management
Head and Neck Neoplasms / pathology*
Humans
Melanoma / pathology*
Parotid Neoplasms / secondary*
Parotid Neoplasms / therapy*
Prognosis