MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons

Eur J Neurosci. 2017 Dec;46(11):2754-2767. doi: 10.1111/ejn.13766. Epub 2017 Nov 22.

Abstract

MAP6 proteins were first described as microtubule-stabilizing agents, whose properties were thought to be essential for neuronal development and maintenance of complex neuronal networks. However, deletion of all MAP6 isoforms in MAP6 KO mice does not lead to dramatic morphological aberrations of the brain but rather to alterations in multiple neurotransmissions and severe behavioural impairments. A search for protein partners of MAP6 proteins identified Tctex1 - a dynein light chain with multiple non-microtubule-related functions. The involvement of Tctex1 in calcium signalling led to investigate it in MAP6 KO neurons. In this study, we show that functional Cav 2.2/N-type calcium channels are deficient in MAP6 KO neurons, due to improper location. We also show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav 2.2/N-type calcium channels. A balance of these two interactions seems to be crucial for MAP6 to modulate calcium signalling in neurons.

Keywords: hippocampal neurons; in vitro interactions; microtubules; plasma membrane; vesicles; yeast two-hybrid.

MeSH terms

  • Animals
  • Binding Sites
  • Calcium Channels, N-Type / metabolism*
  • Calcium Signaling / physiology*
  • Cells, Cultured
  • Dyneins / metabolism*
  • Female
  • Hippocampus / cytology
  • Mice
  • Mice, Knockout
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism*
  • Neurons / metabolism*
  • Protein Binding

Substances

  • Cacna1b protein, mouse
  • Calcium Channels, N-Type
  • Dynlt1b protein, mouse
  • Microtubule-Associated Proteins
  • Mtap6 protein, mouse
  • Dyneins

Associated data

  • GENBANK/NP_058900
  • GENBANK/CAA05555
  • GENBANK/NP_033368
  • GENBANK/NP_000709