Fine-tuning PERK signaling to control cell fate under stress

Nat Struct Mol Biol. 2017 Oct 5;24(10):789-790. doi: 10.1038/nsmb.3478.

Authors

Hery Urra¹, Claudio Hetz^{1

2}

Affiliations

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile, the Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, and the Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
² Buck Institute for Research in Aging, Novato, California, USA and in the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

PMID: 28981072
DOI: 10.1038/nsmb.3478

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Apoptosis / genetics
Endoplasmic Reticulum / metabolism*
Endoplasmic Reticulum Chaperone BiP
Feedback, Physiological
Gene Expression Regulation
HEK293 Cells
Heat-Shock Proteins / genetics
Heat-Shock Proteins / metabolism
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Intracellular Signaling Peptides and Proteins / metabolism
Membrane Proteins / genetics*
Membrane Proteins / metabolism
Mice
Mice, Knockout
Protein Binding
Signal Transduction*
Transcription Factor CHOP / genetics*
Transcription Factor CHOP / metabolism
Unfolded Protein Response*
eIF-2 Kinase / genetics*
eIF-2 Kinase / metabolism

Substances

Canopy 2 protein, mouse
Ddit3 protein, mouse
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Transcription Factor CHOP
PERK kinase
eIF-2 Kinase