The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching

Nucleic Acids Res. 2017 Jan 4;45(D1):D758-D768. doi: 10.1093/nar/gkw1116. Epub 2016 Nov 28.

Abstract

The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data. ZFIN curators provide expert manual curation and integration of comprehensive data involving zebrafish genes, mutants, transgenic constructs and lines, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical structures, models of human disease and publications. We integrate curated, directly submitted, and collaboratively generated data, making these available to zebrafish research community. Among the vertebrate model organisms, zebrafish are superbly suited for rapid generation of sequence-targeted mutant lines, characterization of phenotypes including gene expression patterns, and generation of human disease models. The recent rapid adoption of zebrafish as human disease models is making management of these data particularly important to both the research and clinical communities. Here, we describe recent enhancements to ZFIN including use of the zebrafish experimental conditions ontology, 'Fish' records in the ZFIN database, support for gene expression phenotypes, models of human disease, mutation details at the DNA, RNA and protein levels, and updates to the ZFIN single box search.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Computational Biology / methods
  • Data Curation
  • Databases, Genetic*
  • Disease Models, Animal
  • Gene Expression
  • Genetic Association Studies / methods*
  • Genetic Predisposition to Disease
  • Genomics / methods*
  • Genotype
  • Humans
  • Mutation
  • Phenotype
  • Search Engine*
  • Zebrafish / genetics*