A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis

J Biomol Struct Dyn. 2017 May;35(7):1559-1567. doi: 10.1080/07391102.2016.1188418. Epub 2016 Aug 2.

Authors

Dimitrios Ntountaniotis¹, Μarianna Vanioti¹, Golfo G Kordopati², Tahsin F Kellici^{1

3}, Konstantinos D Marousis⁴, Thomas Mavromoustakos¹, Georgios A Spyroulias⁴, Simona Golic Grdadolnik⁵, Theodore V Tselios²

Affiliations

¹ a Department of Chemistry , National and Kapodistrian University of Athens , Zografou 15771 , Athens , Greece.
² b Department of Chemistry , University of Patras , Patras 26504 , Greece.
³ c Department of Chemistry , University of Ioannina , Ioannina 45110 , Greece.
⁴ d Department of Pharmacy , University of Patras , Patras 26504 , Greece.
⁵ e Department of Biomolecular Structure , National Institute of Chemistry , Hajdrihova 19, SI-1001 Ljubljana , Slovenia.

PMID: 27483998
DOI: 10.1080/07391102.2016.1188418

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental / immunology*
Encephalomyelitis, Autoimmune, Experimental / pathology
Encephalomyelitis, Autoimmune, Experimental / therapy
Epitopes / chemistry
Epitopes / immunology
Mice
Molecular Conformation*
Molecular Dynamics Simulation
Myelin-Oligodendrocyte Glycoprotein / chemistry*
Myelin-Oligodendrocyte Glycoprotein / genetics
Myelin-Oligodendrocyte Glycoprotein / immunology
Myelin-Oligodendrocyte Glycoprotein / metabolism
Nuclear Magnetic Resonance, Biomolecular
Oligodendroglia / immunology
Oligodendroglia / pathology
Peptide Fragments / chemistry
Peptide Fragments / genetics
Peptide Fragments / immunology
Rats

Substances

Epitopes
Myelin-Oligodendrocyte Glycoprotein
Peptide Fragments
myelin oligodendrocyte glycoprotein (35-55)