Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice

Leukemia. 2016 Mar;30(3):749-53. doi: 10.1038/leu.2015.173. Epub 2015 Jul 2.

Authors

K Hartmann¹, A Illing¹, F Leithäuser², A Baisantry¹, L Quintanilla-Martinez³, K L Rudolph^{1

4}

Affiliations

¹ Cooperation Group of the Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Jena and Ulm University (UULM), Ulm, Germany.
² Department of Pathology, University Hospital of Ulm, Ulm, Germany.
³ Institute of Pathology, University Hospital Tübingen, Tübingen, Germany.
⁴ Faculty of Medicine, Research Group on Molecular Aging, University Hospital Jena (UKJ), Friedrich-Schiller-University (FSU), Jena, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics*
Aging / metabolism
Animals
Bone Marrow / metabolism
Bone Marrow / pathology
DNA Damage
Disease Models, Animal
Gene Dosage*
Gene Expression Regulation, Neoplastic*
Heterozygote
Humans
Lymphoma / genetics*
Lymphoma / metabolism
Lymphoma / pathology
Metaphase
Mice
Signal Transduction
Survival Analysis
Telomere / chemistry
Telomere Shortening*
Telomere-Binding Proteins / deficiency
Telomere-Binding Proteins / genetics*
Telomeric Repeat Binding Protein 1 / deficiency
Telomeric Repeat Binding Protein 1 / genetics*

Substances

Telomere-Binding Proteins
Telomeric Repeat Binding Protein 1
Tinf2 protein, mouse