New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Infect Genet Evol. 2015 Jun:32:322-6. doi: 10.1016/j.meegid.2015.03.028. Epub 2015 Mar 31.

Abstract

Influenza A(H1N1)pdm09 virus has evolved continually since its emergence in 2009. For influenza virus strains, genetic changes occurring in HA1 domain of the hemagglutinin cause the emergence of new variants. The aim of our study is to establish genetic associations between 35 A(H1N1)pdm09 viruses circulating in Cuba in 2011-2012 and 2012-2013 seasons, and A/California/07/2009 strain recommended by WHO as the H1N1 component of the influenza vaccine. The phylogenetic analysis revealed the circulation of clades 3, 6A, 6B, 6C and 7. Mutations were detected in the antigenic site or in the receptor-binding domains of HA1 segment, including S174P, S179N, K180Q, S202T, S220T and R222K. Substitutions S174P, S179N, K180Q and R222K were detected in Cuban strains for the first time.

Keywords: Cuba; Genetic variants; Influenza.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral / genetics
  • Cuba
  • DNA Mutational Analysis
  • Genetic Association Studies
  • Genetic Variation*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Humans
  • Influenza A Virus, H1N1 Subtype / classification
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza, Human / virology*
  • Phylogeny
  • Protein Conformation

Substances

  • Antigens, Viral
  • Hemagglutinin Glycoproteins, Influenza Virus