TNNI3K in cardiovascular disease and prospects for therapy

J Mol Cell Cardiol. 2015 May:82:167-73. doi: 10.1016/j.yjmcc.2015.03.008. Epub 2015 Mar 16.

Abstract

Cardiovascular diseases are an important cause of morbidity and mortality worldwide and the global burden of these diseases continues to grow. Therefore new therapies are urgently needed. The role of protein kinases in disease, including cardiac disease, is long recognized, making kinases important therapeutic targets. We here review the knowledge gathered in the last decade about troponin I-interacting kinase (TNNI3K), a kinase with cardiac-restricted expression that has been implicated in various cardiac phenotypes and diseases including heart failure, cardiomyopathy, ischemia/reperfusion injury and conduction of the cardiac electrical impulse.

Keywords: Arrhythmia; Heart failure; Ischemia/reperfusion; Kinase; Tnni3k.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism*
  • Cardiovascular Diseases / physiopathology
  • Gene Expression Regulation
  • Humans
  • MAP Kinase Kinase Kinases / chemistry
  • MAP Kinase Kinase Kinases / genetics*
  • MAP Kinase Kinase Kinases / metabolism*
  • Myocardium / metabolism
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Serine-Threonine Kinases
  • Protein Transport

Substances

  • Protein Serine-Threonine Kinases
  • TNNI3K protein, human
  • MAP Kinase Kinase Kinases