[Genetic studies of primary open-angle glaucoma]

Vestn Oftalmol. 2014 Sep-Oct;130(5):96-9.
[Article in Russian]

Abstract

The present review is devoted to genetic studies of primary open-angle glaucoma (POAG). Today, POAG is considered a multifactorial disease with threshold effect, which is associated with single or multiple genes mutation as well as external influences. According to molecular genetic studies, three causative genes (MYOC, optinevrin, WDR 36) and several dosens of candidate genes are involved in the development of POAG.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins
  • Cytoskeletal Proteins / genetics
  • Eye Proteins / genetics*
  • Genetic Association Studies*
  • Genetic Predisposition to Disease
  • Glaucoma, Open-Angle / genetics*
  • Glycoproteins / genetics
  • Humans
  • Membrane Transport Proteins
  • Mutation
  • Transcription Factor TFIIIA / genetics

Substances

  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • Eye Proteins
  • Glycoproteins
  • Membrane Transport Proteins
  • OPTN protein, human
  • Transcription Factor TFIIIA
  • WDR36 protein, human
  • trabecular meshwork-induced glucocorticoid response protein