Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis

Leukemia. 2015 Mar;29(3):753-7. doi: 10.1038/leu.2014.316. Epub 2014 Nov 5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / genetics
  • Antigens, CD / metabolism
  • Blood Platelets / metabolism
  • Blood Platelets / pathology
  • Cell Differentiation
  • Cell Lineage / genetics
  • Cell Proliferation
  • Core Binding Factor beta Subunit / deficiency
  • Core Binding Factor beta Subunit / genetics*
  • Gene Expression Regulation, Developmental*
  • Hematopoiesis / genetics*
  • Hemoglobins / metabolism
  • Humans
  • Leukocytes / metabolism
  • Leukocytes / pathology
  • Mice
  • Mice, Knockout
  • Pancytopenia / genetics*
  • Pancytopenia / metabolism
  • Pancytopenia / mortality
  • Pancytopenia / pathology
  • Platelet Count
  • Stem Cells / metabolism*
  • Stem Cells / pathology
  • Survival Analysis

Substances

  • Antigens, CD
  • Cbfb protein, mouse
  • Core Binding Factor beta Subunit
  • Hemoglobins