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The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression.
PLoS One. 2014 Oct 7;9(10):e109159. doi: 10.1371/journal.pone.0109159. eCollection 2014.
PLoS One. 2014.
PMID: 25290918
Free PMC article.
NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS.
Widenmaier SB, et al.
Cell. 2017 Nov 16;171(5):1094-1109.e15. doi: 10.1016/j.cell.2017.10.003.
Cell. 2017.
PMID: 29149604
Free article.
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