Protoporphyrinogen oxidase inhibition by three peroxidizing herbicides: oxadiazon, LS 82-556 and M&B 39279

FEBS Lett. 1989 Mar 13;245(1-2):35-8. doi: 10.1016/0014-5793(89)80186-3.

Abstract

Three chemically unrelated peroxidizing molecules, namely oxadiazon [5-(t-butyl)-3-(2,4-dichloro-5-isopropoxyphenyl)-1,3,4-oxadiazol-2 -one], LS 82-556 [(S)3-N-(methylbenzyl)carbamoyl-5-propionyl-2,6-lutidine] and M&B 39279 [5-amino-4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazol], are potent inhibitors of plant, yeast and mouse protoporphyrinogen oxidase.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chloroplasts / enzymology
  • Flavoproteins
  • Herbicides / pharmacology
  • Mice
  • Mice, Inbred DBA
  • Mitochondria / enzymology
  • Mitochondria, Liver / enzymology
  • Mitochondrial Proteins
  • Niacinamide / analogs & derivatives*
  • Niacinamide / pharmacology
  • Oxadiazoles / pharmacology*
  • Oxidoreductases / antagonists & inhibitors*
  • Oxidoreductases Acting on CH-CH Group Donors*
  • Plants / enzymology
  • Protoporphyrinogen Oxidase
  • Pyrazoles / pharmacology*
  • Saccharomyces cerevisiae / enzymology
  • Solanum tuberosum
  • Zea mays

Substances

  • Flavoproteins
  • Herbicides
  • Mitochondrial Proteins
  • Oxadiazoles
  • Pyrazoles
  • M&B 39279
  • Niacinamide
  • LS 82-556
  • oxadiazon
  • Oxidoreductases
  • Oxidoreductases Acting on CH-CH Group Donors
  • Ppox protein, mouse
  • Protoporphyrinogen Oxidase