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Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.
Virol J. 2014 Jun 9;11:108. doi: 10.1186/1743-422X-11-108.
Virol J. 2014.
PMID: 24912982
Free PMC article.
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest.
Belzile JP, Richard J, Rougeau N, Xiao Y, Cohen EA.
Belzile JP, et al.
J Virol. 2010 Apr;84(7):3320-30. doi: 10.1128/JVI.02590-09. Epub 2010 Jan 20.
J Virol. 2010.
PMID: 20089662
Free PMC article.
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