Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment

Psychiatry Res. 2013 Dec 30;210(3):1290-2. doi: 10.1016/j.psychres.2013.09.016. Epub 2013 Oct 7.

Abstract

Little is known about how genes expressed in blood relate to schizophrenia or antipsychotic use. We analyzed gene expression in 10 first-episode psychosis patients and nine controls using PCR Arrays. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use.

Keywords: CHRNA3; GABRR2; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Brazil
  • Down-Regulation
  • Female
  • Gene Expression / drug effects
  • Humans
  • Male
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / blood
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / psychology
  • RNA, Messenger / blood
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / genetics*
  • Receptors, Neurotransmitter / blood
  • Receptors, Neurotransmitter / genetics*
  • Receptors, Nicotinic / drug effects
  • Receptors, Nicotinic / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risperidone / therapeutic use*
  • Schizophrenia / drug therapy
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • GABRR2 protein, human
  • RNA, Messenger
  • Receptors, GABA-A
  • Receptors, Neurotransmitter
  • Receptors, Nicotinic
  • nicotinic receptor subunit alpha3
  • Risperidone