Antibiotic resistance determinants of multidrug-resistant Acinetobacter baumannii clinical isolates in Algeria

Diagn Microbiol Infect Dis. 2013 Aug;76(4):529-31. doi: 10.1016/j.diagmicrobio.2013.04.009. Epub 2013 May 18.

Abstract

Antibiotic susceptibility testing was performed on 71 Acinetobacter baumannii clinical isolates, and presence of antibiotic resistance genes was screened for by PCR amplification and sequencing. Resistance rates were very high for aminoglycosides (22-80%), fluoroquinolones (>90%), and cephalosporins (>90%) but remained low for rifampin (2.8%) or null for colistin. Antibiotic resistance encoding genes detected were as follows: blaTEM-128 gene (74.6%), aph(3')-VI (50.7 %), aadA (63.4%), ant(2″)-I (14.1%), aac(3)-Ia (91.1%), aac(6')-Ib (4.2%), mutation Ser83Leu in gyrA (94.4%), double mutations Ser83Leu and Ser80Leu (or Ser84Leu) in gyrA and parC (69.0%), and mutation I581N in RRDR of the rpoB gene.

Keywords: Acinetobacter baumannii; Aminoglycoside-modifying enzymes; Multidrug resistant bacteria; Rifampin resistance.

MeSH terms

  • Acinetobacter Infections / drug therapy*
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Acinetobacter baumannii / metabolism
  • Anti-Bacterial Agents / classification
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / classification
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Phylogeny

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins