Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits

Psychiatry Res. 2013 Aug 30;209(1):110-3. doi: 10.1016/j.psychres.2013.03.035. Epub 2013 Apr 23.

Abstract

We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.

Keywords: Cognition; Executive functions; Gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Adult
  • Analysis of Variance
  • Attention / physiology
  • Cognition Disorders / etiology
  • Cognition Disorders / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Inhibition, Psychological
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Neuropsychological Tests
  • Polymorphism, Single Nucleotide / genetics*
  • Proteins / genetics*
  • Schizophrenia / complications
  • Schizophrenia / genetics*
  • Verbal Learning

Substances

  • Adaptor Proteins, Vesicular Transport
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • UFD1 protein, human