Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia

Haematologica. 2012 Sep;97(9):1447-50. doi: 10.3324/haematol.2012.065730. Epub 2012 May 11.

Authors

Rishi S Kotecha¹, Jette Ford, Alex H Beesley, Denise Anderson, Catherine H Cole, Ursula R Kees

Affiliation

¹ Department of Haematology and Oncology, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia. rishi_k28@hotmail.com

No abstract available

Publication types

Twin Study

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 4 / genetics
DNA Copy Number Variations / genetics*
Gene Rearrangement
Histone-Lysine N-Methyltransferase
Humans
Infant
Myeloid-Lymphoid Leukemia Protein / genetics*
Oncogene Proteins, Fusion / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Prognosis
Translocation, Genetic / genetics*
Twins, Monozygotic / genetics*

Substances

Adaptor Proteins, Signal Transducing
EPS15 protein, human
KMT2A protein, human
Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase