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Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Chauhan S, Diril MK, Lee JH, Bisteau X, Manoharan V, Adhikari D, Ratnacaram CK, Janela B, Noffke J, Ginhoux F, Coppola V, Liu K, Tessarollo L, Kaldis P. Chauhan S, et al. Biochem J. 2016 Sep 15;473(18):2783-98. doi: 10.1042/BCJ20160607. Epub 2016 Jul 1. Biochem J. 2016. PMID: 27371320 Free PMC article.
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.
Teitz T, Fang J, Goktug AN, Bonga JD, Diao S, Hazlitt RA, Iconaru L, Morfouace M, Currier D, Zhou Y, Umans RA, Taylor MR, Cheng C, Min J, Freeman B, Peng J, Roussel MF, Kriwacki R, Guy RK, Chen T, Zuo J. Teitz T, et al. J Exp Med. 2018 Apr 2;215(4):1187-1203. doi: 10.1084/jem.20172246. Epub 2018 Mar 7. J Exp Med. 2018. PMID: 29514916 Free PMC article.
Cdk2 knockout mice are viable.
Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Berthet C, et al. Curr Biol. 2003 Oct 14;13(20):1775-85. doi: 10.1016/j.cub.2003.09.024. Curr Biol. 2003. PMID: 14561402 Free article.