Recurrent pyogenic meningitis in a 17-year-old: a delayed presentation of X-linked agammaglobulinemia with growth hormone deficiency

Neurol India. 2011 May-Jun;59(3):435-7. doi: 10.4103/0028-3886.82768.

Abstract

We report an adolescent male with X-linked agammaglobulinemia (XLA) and recurrent episodes of pyogenic meningitis. The workup for proportionate short stature revealed isolated growth hormone deficiency. This patient highlights the delayed presentation of the XLA variant and the need to consider primary immunodeficiency in patients with recurrent serious infections, irrespective of age.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Agammaglobulinemia / complications*
  • Agammaglobulinemia / genetics*
  • Anti-Bacterial Agents / therapeutic use
  • Blood Protein Electrophoresis
  • Body Height
  • Genetic Diseases, X-Linked / complications*
  • Genetic Diseases, X-Linked / genetics*
  • Human Growth Hormone / deficiency*
  • Humans
  • Lymphocyte Count
  • Male
  • Meningitis / etiology
  • Meningitis / immunology
  • Meningitis / pathology*
  • Recurrence
  • Vomiting / complications

Substances

  • Anti-Bacterial Agents
  • Human Growth Hormone

Supplementary concepts

  • Bruton type agammaglobulinemia