Abstract
Regulator of G-protein signaling protein (RGS)-2 is a modulator of anxiety and dysregulation of oxidative stress is implicated in anxiety. Also, RGS2 expression is reported to be induced by oxidative stress. Thus, if oxidative stress induces RGS2 expression and lack of RGS2 causes anxiety, then mechanisms that link RGS2 and oxidative stress potentially critical to anxiety must be revealed. Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of p38 MAPK and PKC pathways in an Sp-1 dependent manner.
Published by Elsevier B.V.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / metabolism*
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Blotting, Western
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Cell Line
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Cell Survival / drug effects
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DNA, Antisense / genetics
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Enzyme Activation / drug effects
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Gene Expression / drug effects
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Glutathione Reductase / genetics
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Glutathione Reductase / metabolism
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Homeostasis*
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Hydrogen Peroxide / pharmacology
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Lactoylglutathione Lyase / genetics
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Lactoylglutathione Lyase / metabolism
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Mice
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Neurons / cytology
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Neurons / drug effects
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Neurons / metabolism*
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Oxidants / pharmacology
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Oxidative Stress / drug effects
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Protein Carbonylation / drug effects
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Protein Kinase C / metabolism
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RGS Proteins / genetics
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RGS Proteins / metabolism*
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction / drug effects
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Superoxide Dismutase / genetics
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Superoxide Dismutase / metabolism
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p38 Mitogen-Activated Protein Kinases / metabolism
Substances
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Antioxidants
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DNA, Antisense
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Oxidants
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RGS Proteins
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Rgs2 protein, mouse
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Hydrogen Peroxide
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Superoxide Dismutase
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Glutathione Reductase
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Protein Kinase C
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p38 Mitogen-Activated Protein Kinases
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Lactoylglutathione Lyase