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Taste preference for fatty acids is mediated by GPR40 and GPR120.
J Neurosci. 2010 Jun 23;30(25):8376-82. doi: 10.1523/JNEUROSCI.0496-10.2010.
J Neurosci. 2010.
PMID: 20573884
Free PMC article.
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P.
Ichimura A, et al.
Nature. 2012 Feb 19;483(7389):350-4. doi: 10.1038/nature10798.
Nature. 2012.
PMID: 22343897
Free article.
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GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.
Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG.
Stone VM, et al.
Diabetologia. 2014 Jun;57(6):1182-91. doi: 10.1007/s00125-014-3213-0. Epub 2014 Mar 25.
Diabetologia. 2014.
PMID: 24663807
Free PMC article.
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Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V.
Croze ML, et al.
Mol Metab. 2021 Mar;45:101166. doi: 10.1016/j.molmet.2021.101166. Epub 2021 Jan 20.
Mol Metab. 2021.
PMID: 33484949
Free PMC article.
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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.
Xiong Y, Swaminath G, Cao Q, Yang L, Guo Q, Salomonis H, Lu J, Houze JB, Dransfield PJ, Wang Y, Liu JJ, Wong S, Schwandner R, Steger F, Baribault H, Liu L, Coberly S, Miao L, Zhang J, Lin DC, Schwarz M.
Xiong Y, et al.
Mol Cell Endocrinol. 2013 Apr 30;369(1-2):119-29. doi: 10.1016/j.mce.2013.01.009. Epub 2013 Feb 9.
Mol Cell Endocrinol. 2013.
PMID: 23403053
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Structural basis for GPR40 allosteric agonism and incretin stimulation.
Ho JD, Chau B, Rodgers L, Lu F, Wilbur KL, Otto KA, Chen Y, Song M, Riley JP, Yang HC, Reynolds NA, Kahl SD, Lewis AP, Groshong C, Madsen RE, Conners K, Lineswala JP, Gheyi T, Saflor MD, Lee MR, Benach J, Baker KA, Montrose-Rafizadeh C, Genin MJ, Miller AR, Hamdouchi C.
Ho JD, et al.
Nat Commun. 2018 Apr 25;9(1):1645. doi: 10.1038/s41467-017-01240-w.
Nat Commun. 2018.
PMID: 29695780
Free PMC article.
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