19890007,20457918,27383589,26824392,20850369,19667187,30048714,19545277,21828077,24427314,18045479,25836420,28576705,27474410,25356398[uid] - Search Results

Year	Number of Results
2007	1
2009	3
2010	2
2011	1
2014	2
2015	1
2016	3
2017	1
2018	1
2024	0

1

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H. Parisiadou L, et al. J Neurosci. 2009 Nov 4;29(44):13971-80. doi: 10.1523/JNEUROSCI.3799-09.2009. J Neurosci. 2009. PMID: 19890007 Free PMC article.

2

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J. Tong Y, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9879-84. doi: 10.1073/pnas.1004676107. Epub 2010 May 10. Proc Natl Acad Sci U S A. 2010. PMID: 20457918 Free PMC article.

3

Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.

Matikainen-Ankney BA, Kezunovic N, Mesias RE, Tian Y, Williams FM, Huntley GW, Benson DL. Matikainen-Ankney BA, et al. J Neurosci. 2016 Jul 6;36(27):7128-41. doi: 10.1523/JNEUROSCI.3314-15.2016. J Neurosci. 2016. PMID: 27383589 Free PMC article.

4

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Steger M, et al. Elife. 2016 Jan 29;5:e12813. doi: 10.7554/eLife.12813. Elife. 2016. PMID: 26824392 Free PMC article.

5

A comparative study of Lrrk2 function in primary neuronal cultures.

Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ. Dächsel JC, et al. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5. doi: 10.1016/j.parkreldis.2010.08.018. Epub 2010 Sep 17. Parkinsonism Relat Disord. 2010. PMID: 20850369 Free PMC article.

6

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. Tong Y, et al. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7. doi: 10.1073/pnas.0906334106. Epub 2009 Aug 10. Proc Natl Acad Sci U S A. 2009. PMID: 19667187 Free PMC article.

7

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.

Kelly K, Wang S, Boddu R, Liu Z, Moukha-Chafiq O, Augelli-Szafran C, West AB. Kelly K, et al. Exp Neurol. 2018 Nov;309:1-13. doi: 10.1016/j.expneurol.2018.07.012. Epub 2018 Jul 24. Exp Neurol. 2018. PMID: 30048714 Free PMC article.

8

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

Gillardon F. Gillardon F. J Neurochem. 2009 Sep;110(5):1514-22. doi: 10.1111/j.1471-4159.2009.06235.x. Epub 2009 Jun 22. J Neurochem. 2009. PMID: 19545277 Free article.

9

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.

Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, Stemmelen C, Troxler TJ, Schmid P, Danner S, Schnell CR, Mueller M, Kinzel B, Grevot A, Bolognani F, Stirn M, Kuhn RR, Kaupmann K, van der Putten PH, Rovelli G, Shimshek DR. Herzig MC, et al. Hum Mol Genet. 2011 Nov 1;20(21):4209-23. doi: 10.1093/hmg/ddr348. Epub 2011 Aug 9. Hum Mol Genet. 2011. PMID: 21828077 Free PMC article.

10

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.

Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, Hébert SS. Dorval V, et al. PLoS One. 2014 Jan 10;9(1):e85510. doi: 10.1371/journal.pone.0085510. eCollection 2014. PLoS One. 2014. PMID: 24427314 Free PMC article.

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