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E2f3 is critical for normal cellular proliferation.
Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA. Humbert PO, et al. Genes Dev. 2000 Mar 15;14(6):690-703. Genes Dev. 2000. PMID: 10733529 Free PMC article.
Mouse development with a single E2F activator.
Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.
Myc requires distinct E2F activities to induce S phase and apoptosis.
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Leone G, et al. Mol Cell. 2001 Jul;8(1):105-13. doi: 10.1016/s1097-2765(01)00275-1. Mol Cell. 2001. PMID: 11511364 Free article.