Abstract
The gene, BTBD9, was recently linked to restless legs syndrome, periodic limb movements and iron status in humans. In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis. This finding is important as iron status in brain has been implicated in restless legs syndrome.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism
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Genome, Human*
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Genomics
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Humans
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Iron / metabolism*
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Mice
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism
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Restless Legs Syndrome / genetics*
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Restless Legs Syndrome / metabolism
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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BTBD9 protein, human
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Btbd9 protein, mouse
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Carrier Proteins
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Nerve Tissue Proteins
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Transcription Factors
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Iron