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Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Hum Mol Genet. 2007 Sep 1;16(17):2072-88. doi: 10.1093/hmg/ddm155. Epub 2007 Jun 22.
Hum Mol Genet. 2007.
PMID: 17588960
Free PMC article.
Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.
Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT.
Posey KL, et al.
Am J Pathol. 2008 Jun;172(6):1664-74. doi: 10.2353/ajpath.2008.071094. Epub 2008 May 8.
Am J Pathol. 2008.
PMID: 18467703
Free PMC article.
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