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Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Genes Cells. 2006 Jan;11(1):83-93. doi: 10.1111/j.1365-2443.2005.00914.x.
Genes Cells. 2006.
PMID: 16371134
Free article.
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Zhao G, Liu Z, Ilagan MX, Kopan R.
Zhao G, et al.
J Neurosci. 2010 Feb 3;30(5):1648-56. doi: 10.1523/JNEUROSCI.3826-09.2010.
J Neurosci. 2010.
PMID: 20130175
Free PMC article.
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