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Negative regulation of Toll-like-receptor signaling by IRF-4.
Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K. Negishi H, et al. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15989-94. doi: 10.1073/pnas.0508327102. Epub 2005 Oct 19. Proc Natl Acad Sci U S A. 2005. PMID: 16236719 Free PMC article.
Compensatory dendritic cell development mediated by BATF-IRF interactions.
Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, KC W, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD, Murphy KM. Tussiwand R, et al. Nature. 2012 Oct 25;490(7421):502-7. doi: 10.1038/nature11531. Epub 2012 Sep 19. Nature. 2012. PMID: 22992524 Free PMC article.
A validated regulatory network for Th17 cell specification.
Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. Ciofani M, et al. Cell. 2012 Oct 12;151(2):289-303. doi: 10.1016/j.cell.2012.09.016. Epub 2012 Sep 25. Cell. 2012. PMID: 23021777 Free PMC article.
IRF4 is a key thermogenic transcriptional partner of PGC-1α.
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. Kong X, et al. Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049. Cell. 2014. PMID: 24995979 Free PMC article.
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F. Bruchard M, et al. Nat Immunol. 2015 Aug;16(8):859-70. doi: 10.1038/ni.3202. Epub 2015 Jun 22. Nat Immunol. 2015. PMID: 26098997