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Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss.
Rüttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, Knirsch M, Arntz C, Langer P, Hirt B, Müller M, Köpschall I, Pfister M, Münkner S, Rohbock K, Pfaff I, Rüsch A, Ruth P, Knipper M. Rüttiger L, et al. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12922-7. doi: 10.1073/pnas.0402660101. Epub 2004 Aug 24. Proc Natl Acad Sci U S A. 2004. PMID: 15328414 Free PMC article.
Two classes of outer hair cells along the tonotopic axis of the cochlea.
Engel J, Braig C, Rüttiger L, Kuhn S, Zimmermann U, Blin N, Sausbier M, Kalbacher H, Münkner S, Rohbock K, Ruth P, Winter H, Knipper M. Engel J, et al. Neuroscience. 2006 Dec;143(3):837-49. doi: 10.1016/j.neuroscience.2006.08.060. Epub 2006 Oct 30. Neuroscience. 2006. PMID: 17074442