Abstract
The predicted protein product of an anonymous clone isolated from a cDNA library prepared from 12 day post coitum (p.c) embryonic mouse heart tissue demonstrated the same segmental repeats previously identified in the cell division control protein, CDC4 and the G protein beta 1 subunit. A search of the protein database subsequently identified three other classes of protein containing the repeat. Secondary structure analyses performed on the repeat sequences revealed a high degree of conservation suggesting that the repeat motif performs a specific function in a diverse range of proteins.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Cycle Proteins*
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Cloning, Molecular
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DNA / genetics
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F-Box Proteins*
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F-Box-WD Repeat-Containing Protein 7
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Fungal Proteins / genetics
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GTP-Binding Proteins / genetics
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Humans
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Mice
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Molecular Sequence Data
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Protein Structure, Secondary
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Proteins / chemistry
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Proteins / genetics*
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Proteins / physiology
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Repetitive Sequences, Nucleic Acid
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Sequence Alignment
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Sequence Homology, Amino Acid
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Ubiquitin-Protein Ligases*
Substances
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Cell Cycle Proteins
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F-Box Proteins
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F-Box-WD Repeat-Containing Protein 7
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FBXW7 protein, human
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Fbxw7 protein, mouse
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Fungal Proteins
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Proteins
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DNA
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Ubiquitin-Protein Ligases
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GTP-Binding Proteins