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Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death.
Hum Mol Genet. 2003 Jul 1;12(13):1485-96. doi: 10.1093/hmg/ddg175.
Hum Mol Genet. 2003.
PMID: 12812977
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh DP, Nguyen DT, Pulst-Korenberg JB, Brice A, Pulst SM.
Huynh DP, et al.
Exp Neurol. 2007 Feb;203(2):531-41. doi: 10.1016/j.expneurol.2006.09.009. Epub 2006 Nov 9.
Exp Neurol. 2007.
PMID: 17097639
Free PMC article.
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