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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Cell. 2002 Aug 23;110(4):489-500. doi: 10.1016/s0092-8674(02)00872-3.
Cell. 2002.
PMID: 12202038
Free article.
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Yabe D, Brown MS, Goldstein JL.
Yabe D, et al.
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12753-8. doi: 10.1073/pnas.162488899. Epub 2002 Sep 19.
Proc Natl Acad Sci U S A. 2002.
PMID: 12242332
Free PMC article.
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