Abstract
Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and their ligands, the ephrins, have been implicated in the formation of topographic projection maps. We show that multiple Eph receptors and ligands are expressed in the hippocampus and its major subcortical projection target, the lateral septum, and that expression of a truncated Eph receptor in the mouse brain results in a pronounced alteration of the hippocamposeptal topographic map. Our observations provide strong support for a critical role of Eph family guidance factors in regulating ontogeny of hippocampal projections.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Axons / metabolism
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Axons / physiology*
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COS Cells
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Chlorocebus aethiops
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Ephrin-A2
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Ephrin-A3
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Ephrin-A5
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Fetal Proteins / biosynthesis
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Fetal Proteins / metabolism*
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Gene Expression
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Hippocampus / metabolism
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Hippocampus / physiology*
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Ligands
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Membrane Proteins / metabolism
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Mice
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Mice, Inbred C3H
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Receptor Protein-Tyrosine Kinases / biosynthesis
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptor, EphA4
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Receptor, EphA5
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Receptor, EphA7
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Transcription Factors / metabolism
Substances
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Ephrin-A2
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Ephrin-A3
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Ephrin-A5
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Fetal Proteins
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Ligands
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Membrane Proteins
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Transcription Factors
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Receptor Protein-Tyrosine Kinases
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Receptor, EphA4
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Receptor, EphA5
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Receptor, EphA7