Abstract
Mice contain a serum factor capable of inactivating some subgroups of murine leukemia viruses. This leukemia virus-inactivating factor (LVIF) is distinct from immunoglobulin and complement; it has been associated with lipoprotein serum fractions and may be an apolipoprotein. The present study demonstrates that some Swiss-derived inbred strains are LVIF negative. Genetic crosses show this factor to be under control of a single gene that maps to distal chromosome 10 at or near the gene encoding a minor serum apolipoprotein, apolipoprotein F (ApoF). To evaluate this gene as a potential candidate for LVIF, the mouse ApoF gene was cloned and sequenced and its expression was assessed in LVIF-positive and -negative mice; no obvious differences were detected, suggesting that LVIF is under the control of a distinct linked gene.
MeSH terms
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Amino Acid Sequence
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Animals
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Antiviral Agents / blood
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Antiviral Agents / chemistry
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Antiviral Agents / genetics*
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Apolipoproteins / blood
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Apolipoproteins / chemistry
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Apolipoproteins / genetics*
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Chromosome Mapping
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Crosses, Genetic
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Genetic Predisposition to Disease*
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Humans
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Leukemia Virus, Murine / drug effects
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Leukemia Virus, Murine / pathogenicity*
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Leukemia Virus, Murine / physiology
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Leukemia, Experimental / genetics*
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Leukemia, Experimental / virology
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Retroviridae Infections / genetics
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Retroviridae Infections / virology
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Sequence Analysis, DNA
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Transcription, Genetic
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Tumor Virus Infections / genetics
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Tumor Virus Infections / virology
Substances
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Antiviral Agents
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Apolipoproteins
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apolipoprotein F
Associated data
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GENBANK/AF411830
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GENBANK/AF411831
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GENBANK/AF411832