Abstract
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actins / metabolism*
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Animals
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COS Cells
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Cloning, Molecular
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Dynamin I
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Dynamins
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GTP Phosphohydrolases / metabolism*
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / metabolism*
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Precipitin Tests
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Protein Binding
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Protein Isoforms / metabolism*
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Synapses / metabolism*
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Two-Hybrid System Techniques
Substances
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Actins
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Nerve Tissue Proteins
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Protein Isoforms
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Shank1 protein, rat
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Shank2 protein, rat
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Dynamin I
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GTP Phosphohydrolases
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Dynamins