Abstract
C2PA is a novel protein that contains a C2 membrane binding domain, a PDZ protein/protein interaction domain, and an ATP/GTP binding domain. C2PA is expressed during embryogenesis from 8.5 days post-coitum (dpc) until birth. After birth, C2PA expression is mainly observed in the post-natal and adult testis. During spermatogenesis, C2PA transcripts are specifically observed in the spermatocytes, whereas spermatogonia and spermatids are negative. Taken together, these results suggest that C2PA might be involved in cell signaling pathways occurring during spermatogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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DNA, Complementary
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GTP-Binding Proteins / classification
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GTP-Binding Proteins / genetics*
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GTP-Binding Proteins / metabolism
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GTPase-Activating Proteins*
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Gene Expression
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Humans
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Male
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Mice
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Molecular Sequence Data
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RGS Proteins
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Sequence Homology, Amino Acid
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Spermatogenesis / physiology*
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Testis / embryology
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Testis / growth & development
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Testis / metabolism*
Substances
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DNA, Complementary
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GTPase-Activating Proteins
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RGS Proteins
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RGS3 protein, human
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Rgs3 protein, mouse
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GTP-Binding Proteins