Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51

Cytogenet Cell Genet. 2000;89(3-4):268-71. doi: 10.1159/000015631.

Abstract

The integrin family of receptors serves as major receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organisation, cell proliferation, survival, and differentiation. The alpha-V integrins consist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesis and angiogenesis, and are therapeutic targets for inhibition of angiogenesis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics*
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2 / genetics
  • Cloning, Molecular
  • DNA / chemistry
  • DNA / genetics
  • Exons
  • Genes / genetics
  • Humans
  • Integrin alphaV
  • Introns
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Sequence Tagged Sites

Substances

  • Antigens, CD
  • Integrin alphaV
  • DNA

Associated data

  • GENBANK/AF251818
  • GENBANK/AF251819
  • GENBANK/AF251820
  • GENBANK/AF251821
  • GENBANK/AF251822
  • GENBANK/AF251823
  • GENBANK/AF251824
  • GENBANK/AF251825
  • GENBANK/AF251826
  • GENBANK/AF251827
  • GENBANK/AF251828
  • GENBANK/AF251829
  • GENBANK/AF251830
  • GENBANK/AF251831
  • GENBANK/AF251832
  • GENBANK/AF251833
  • GENBANK/AF251834
  • GENBANK/AF251835
  • GENBANK/AF251836
  • GENBANK/AF251837
  • GENBANK/AF251838
  • GENBANK/AF251839
  • GENBANK/AF251840
  • GENBANK/AF251841