Abstract
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Androgen-Binding Protein*
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Base Sequence
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Carrier Proteins / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 17*
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Cloning, Molecular
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DNA, Complementary / genetics
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DNA, Complementary / isolation & purification
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Gene Expression
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Humans
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Molecular Sequence Data
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Organ Specificity
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Phosphatidylethanolamine Binding Protein
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Phospholipid Transfer Proteins
Substances
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Androgen-Binding Protein
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Carrier Proteins
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DNA, Complementary
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PEBP1 protein, human
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Phosphatidylethanolamine Binding Protein
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Phospholipid Transfer Proteins
Associated data
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GENBANK/AF114430
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GENBANK/AF114431
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GENBANK/AF114432
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GENBANK/AF114433
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GENBANK/AF114434
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GENBANK/AF114435
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GENBANK/AF114436
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GENBANK/AF114437