Abstract
The close homologue of L1 (CHL1), a member of the L1 family of neural adhesion molecules, is first expressed at times of neurite outgrowth during brain development, and is detectable in subpopulations of neurons, astrocytes, oligodendrocyte precursors and Schwann cells of the mouse and rat. Aggregation assays with CHL1-transfected cells show that CHL1 does not promote homophilic adhesion or does it mediate heterophilic adhesion with L1. CHL1 promotes neurite outgrowth by hippocampal and small cerebellar neurons in substrate-bound and soluble form. The observation that CHL1 and L1 show overlapping, but also distinct patterns of synthesis in neurons and glia, suggests differential effects of L1-like molecules on neurite outgrowth.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blotting, Western
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Brain Chemistry / physiology*
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COS Cells
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Cell Adhesion Molecules
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Drosophila
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Gene Expression / physiology
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Hippocampus / chemistry
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Hippocampus / cytology
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In Situ Hybridization
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Mice
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Mice, Inbred ICR
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism
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Neural Cell Adhesion Molecule L1*
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Neural Cell Adhesion Molecules / analysis
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Neural Cell Adhesion Molecules / genetics*
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Neural Cell Adhesion Molecules / metabolism
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Neurites / chemistry*
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Neurites / metabolism
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Neurons / chemistry
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Neurons / physiology
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Neurons / ultrastructure
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Oligodendroglia / cytology
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Peripheral Nerves / chemistry
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Peripheral Nerves / cytology
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Peripheral Nerves / metabolism
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Protein Binding / physiology
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Proteins*
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RNA, Messenger / analysis
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Rabbits
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Rats
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Thalamus / chemistry
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Thalamus / cytology
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Transfection
Substances
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Cell Adhesion Molecules
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Chl1 protein, mouse
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Nerve Tissue Proteins
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Neural Cell Adhesion Molecule L1
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Neural Cell Adhesion Molecules
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Proteins
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RNA, Messenger