SHC-transforming protein 1 isoform X14 [Homo sapiens]

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View conserved domains detected in this protein sequence using CD-search.
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Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions. [Diabetes. 2022]
The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions.
Biondi G, Marrano N, Dipaola L, Borrelli A, Rella M, D'Oria R, Genchi VA, Caccioppoli C, Porreca I, Cignarelli A, et al. Diabetes. 2022 Aug 1; 71(8):1763-1771.
Lower p66Shc promoter methylation in subjects with chronic renal failure. [PLoS One. 2021]
Lower p66Shc promoter methylation in subjects with chronic renal failure.
Hamdi R, Saadallah-Kallel A, Ferchichi-Trimeche S, Mokdad-Gargouri R, Miled A, Benarba B. PLoS One. 2021; 16(9):e0257176. Epub 2021 Sep 16.
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner. [Mol Biol Cell. 2021]
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner.
Yoshizawa R, Umeki N, Yamamoto A, Okada M, Murata M, Sako Y. Mol Biol Cell. 2021 Sep 1; 32(19):1838-1848. Epub 2021 Jul 14.

RefSeq genomic sequence
See the genomic reference sequence for the SHC1 gene (NG_029028.1).
RefSeq mRNA
See reference mRNA sequence for the SHC1 gene (XM_047427970.1).
RefSeq protein isoforms
See 79 reference sequence protein isoforms for the SHC1 gene.