RecName: Full=Mitogen-activated protein kinase kinase kinase 12; AltNa - Protein

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A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. [Ann Clin Transl Neurol. 2022]
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
Katz JS, Rothstein JD, Cudkowicz ME, Genge A, Oskarsson B, Hains AB, Chen C, Galanter J, Burgess BL, Cho W, et al. Ann Clin Transl Neurol. 2022 Jan; 9(1):50-66. Epub 2022 Jan 10.
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity. [Acta Neuropathol Commun. 2019]
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH. Acta Neuropathol Commun. 2019 Jun 4; 7(1):93. Epub 2019 Jun 4.
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. [Sci Transl Med. 2017]
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, et al. Sci Transl Med. 2017 Aug 16; 9(403).

RefSeq protein isoforms
See 10 reference sequence protein isoforms for the Map3k12 gene.

PubMed
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MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Mouse Genome Informatics (MGI) [Mouse Genome Informatics (MGI)]
Mouse Genome Informatics (MGI)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

Homologene neighbors for GEO Profiles (Select 115391903) (0)
GEO Profiles
cortistatin preproprotein [Ovis aries]
cortistatin preproprotein [Ovis aries]
gi|527317363|ref|NP_001137363.2|

Protein
PMC Links for Nucleotide (Select 12834452) (2)
PMC
ankyrin repeat domain-containing protein 27 isoform X1 [Gallus gallus]
ankyrin repeat domain-containing protein 27 isoform X1 [Gallus gallus]
gi|2201744786|ref|XP_046781477.1|

Protein
Rnf139 ring finger protein 139 [Mus musculus]
Rnf139 ring finger protein 139 [Mus musculus]
Gene ID:75841

Gene

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Protein