Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, et al. Am J Physiol Heart Circ Physiol. 2015 Aug 1; 309(3):H434-49. Epub 2015 Jun 8.