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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
We profiled the methylation landscape of ~2100 DNA samples (~1100 cases of colorectal cancer and ~1000 controls) from the Ontario Familial Colon Cancer Registry (OFCCR) using the HumanMethylation450 array from Illumina. DNA was extracted from lymphocyte pellets, except for 99 samples for which DNA was extracted from lymphoblastoid cell lines. Samples were genotyped on the Affymetrix Human Mapping 100k and 500k arrays. The aim the study was to evaluate the interplay between genetic variation and methylation, including long-range epigenetic regulation.
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 2402
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
The cases and controls used in this study were enrolled in phase I of the Ontario Familial Colon Cancer Registry (OFCCR). Probands were selected from incident colorectal cancer cases identified between July 1,1997 and June 30, 2000 from the population-based Ontario Cancer Registry. Controls were recruited through telephone interviews in randomly selected households in Ontario.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Affymetrix Mapping250K_Nsp 262264 33767 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays Whole Genome Genotyping Affymetrix Mapping250K_Sty 238304 33766 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays Whole Genome Genotyping Affymetrix Mapping50K_Hind240 57449 33750 Affymetrix 100K Set comprises Mapping50K_Hind240 and Mapping50K_Xba240 Arrays Whole Genome Genotyping Affymetrix Mapping50K_Xba240 58960 33751 Affymetrix 100K Set comprises Mapping50K_Hind240 and Mapping50K_Xba240 Arrays Methylation Illumina Human Methylation 450 v.1.1 N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Colorectal Neoplasms
- Links to Related Resources
- Authorized Data Access Requests
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See research articles citing use of the data from this study
- Study Attribution
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Principal Investigator
- Thomas J. Hudson. Ontatio Institute for Cancer Research, Toronto, Ontario, Canada.
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Principal Investigator