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Items: 1 to 20 of 51

1.
A Novel Isoform of the B Cell Tyrosine Kinase BTK Protects Breast Cancer Cells from Apoptosis
Cheryl Eifert, Xianhui Wang, Leila Kokabee, Antonis Kourtidis, Ritu Jain, Michael J. Gerdes, Douglas S. Conklin
Genes Chromosomes Cancer. Author manuscript; available in PMC 2016 Aug 31.
Published in final edited form as: Genes Chromosomes Cancer. 2013 Oct; 52(10): 961–975. Published online 2013 Aug 3. doi: 10.1002/gcc.22091
PMCID:
PMC5006942
AbstractArticlePDF–1.2M
2.
Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Richard R. Furman, Shuhua Cheng, Pin Lu, Menu Setty, Alexendar R. Perez, Ailin Guo, Joelle Racchumi, Guozhou Xu, Hao Wu, Jiao Ma, Susanne M. Steggerda, Morton Coleman, Christina Leslie, Y. Lynn Wang
N Engl J Med. Author manuscript; available in PMC 2015 Jul 23.
Published in final edited form as: N Engl J Med. 2014 Jun 12; 370(24): 2352–2354. Published online 2014 May 28. doi: 10.1056/NEJMc1402716
Correction in:
volume 370 on page 2547
PMCID:
PMC4512173
ArticlePDF–163K
3.
Resistance Mechanisms for the Bruton’s Tyrosine Kinase Inhibitor Ibrutinib
Jennifer A. Woyach, Richard R. Furman, Ta-Ming Liu, Hatice Gulcin Ozer, Marc Zapatka, Amy S. Ruppert, Ling Xue, Daniel Hsieh-Hsin Li, Susanne M. Steggerda, Matthias Versele, Sandeep S. Dave, Jenny Zhang, Ayse Selen Yilmaz, Samantha M. Jaglowski, Kristie A. Blum, Arletta Lozanski, Gerard Lozanski, Danelle F. James, Jacqueline C. Barrientos, Peter Lichter, Stephan Stilgenbauer, Joseph J. Buggy, Betty Y. Chang, Amy J. Johnson, John C. Byrd
N Engl J Med. Author manuscript; available in PMC 2014 Dec 12.
Published in final edited form as: N Engl J Med. 2014 Jun 12; 370(24): 2286–2294. Published online 2014 May 28. doi: 10.1056/NEJMoa1400029
PMCID:
PMC4144824
AbstractArticlePDF–1.5M
4.
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures
Andreas Kuglstatter, April Wong, Stan Tsing, Simon W Lee, Yan Lou, Armando G Villaseñor, J Michael Bradshaw, David Shaw, Jim W Barnett, Michelle F Browner
Protein Sci. 2011 Feb; 20(2): 428–436. Published online 2010 Dec 17. doi: 10.1002/pro.575
PMCID:
PMC3048427
AbstractArticlePDF–463K
5.
Initial characterization of the human central proteome
Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge
BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17
PMCID:
PMC3039570
AbstractArticlePDF–2.3M
6.
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
Douglas J Marcotte, Yu-Ting Liu, Robert M Arduini, Catherine A Hession, Konrad Miatkowski, Craig P Wildes, Patrick F Cullen, Victor Hong, Brian T Hopkins, Elisabeth Mertsching, Tracy J Jenkins, Michael J Romanowski, Darren P Baker, Laura F Silvian
Protein Sci. 2010 Mar; 19(3): 429–439. Published online 2010 Jan 5. doi: 10.1002/pro.321
PMCID:
PMC2866269
AbstractArticlePDF–500K
7.
Patterns of somatic mutation in human cancer genomes
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton
Nature. Author manuscript; available in PMC 2009 Jul 20.
Published in final edited form as: Nature. 2007 Mar 8; 446(7132): 153–158. doi: 10.1038/nature05610
PMCID:
PMC2712719
AbstractArticlePDF–867K
8.
Large-scale Proteomics Analysis of the Human Kinome
Felix S. Oppermann, Florian Gnad, Jesper V. Olsen, Renate Hornberger, Zoltán Greff, György Kéri, Matthias Mann, Henrik Daub
Mol Cell Proteomics. 2009 Jul; 8(7): 1751–1764. Published online 2009 Apr 15. doi: 10.1074/mcp.M800588-MCP200
PMCID:
PMC2709199
AbstractArticlePDF–993K
9.
The DNA sequence of the human X chromosome
Mark T. Ross, Darren V. Grafham, Alison J. Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, Gareth R. Howell, Christine Burrows, Christine P. Bird, Adam Frankish, Frances L. Lovell, Kevin L. Howe, Jennifer L. Ashurst, Robert S. Fulton, Ralf Sudbrak, Gaiping Wen, Matthew C. Jones, Matthew E. Hurles, T. Daniel Andrews, Carol E. Scott, Stephen Searle, Juliane Ramser, Adam Whittaker, Rebecca Deadman, Nigel P. Carter, Sarah E. Hunt, Rui Chen, Andrew Cree, Preethi Gunaratne, Paul Havlak, Anne Hodgson, Michael L. Metzker, Stephen Richards, Graham Scott, David Steffen, Erica Sodergren, David A. Wheeler, Kim C. Worley, Rachael Ainscough, Kerrie D. Ambrose, M. Ali Ansari-Lari, Swaroop Aradhya, Robert I. S. Ashwell, Anne K. Babbage, Claire L. Bagguley, Andrea Ballabio, Ruby Banerjee, Gary E. Barker, Karen F. Barlow, Ian P. Barrett, Karen N. Bates, David M. Beare, Helen Beasley, Oliver Beasley, Alfred Beck, Graeme Bethel, Karin Blechschmidt, Nicola Brady, Sarah Bray-Allen, Anne M. Bridgeman, Andrew J. Brown, Mary J. Brown, David Bonnin, Elspeth A. Bruford, Christian Buhay, Paula Burch, Deborah Burford, Joanne Burgess, Wayne Burrill, John Burton, Jackie M. Bye, Carol Carder, Laura Carrel, Joseph Chako, Joanne C. Chapman, Dean Chavez, Ellson Chen, Guan Chen, Yuan Chen, Zhijian Chen, Craig Chinault, Alfredo Ciccodicola, Sue Y. Clark, Graham Clarke, Chris M. Clee, Sheila Clegg, Kerstin Clerc-Blankenburg, Karen Clifford, Vicky Cobley, Charlotte G. Cole, Jen S. Conquer, Nicole Corby, Richard E. Connor, Robert David, Joy Davies, Clay Davis, John Davis, Oliver Delgado, Denise DeShazo, Pawandeep Dhami, Yan Ding, Huyen Dinh, Steve Dodsworth, Heather Draper, Shannon Dugan-Rocha, Andrew Dunham, Matthew Dunn, K. James Durbin, Ireena Dutta, Tamsin Eades, Matthew Ellwood, Alexandra Emery-Cohen, Helen Errington, Kathryn L. Evans, Louisa Faulkner, Fiona Francis, John Frankland, Audrey E. Fraser, Petra Galgoczy, James Gilbert, Rachel Gill, Gernot Glöckner, Simon G. Gregory, Susan Gribble, Coline Griffiths, Russell Grocock, Yanghong Gu, Rhian Gwilliam, Cerissa Hamilton, Elizabeth A. Hart, Alicia Hawes, Paul D. Heath, Katja Heitmann, Steffen Hennig, Judith Hernandez, Bernd Hinzmann, Sarah Ho, Michael Hoffs, Phillip J. Howden, Elizabeth J. Huckle, Jennifer Hume, Paul J. Hunt, Adrienne R. Hunt, Judith Isherwood, Leni Jacob, David Johnson, Sally Jones, Pieter J. de Jong, Shirin S. Joseph, Stephen Keenan, Susan Kelly, Joanne K. Kershaw, Ziad Khan, Petra Kioschis, Sven Klages, Andrew J. Knights, Anna Kosiura, Christie Kovar-Smith, Gavin K. Laird, Cordelia Langford, Stephanie Lawlor, Margaret Leversha, Lora Lewis, Wen Liu, Christine Lloyd, David M. Lloyd, Hermela Loulseged, Jane E. Loveland, Jamieson D. Lovell, Ryan Lozado, Jing Lu, Rachael Lyne, Jie Ma, Manjula Maheshwari, Lucy H. Matthews, Jennifer McDowall, Stuart McLaren, Amanda McMurray, Patrick Meidl, Thomas Meitinger, Sarah Milne, George Miner, Shailesh L. Mistry, Margaret Morgan, Sidney Morris, Ines Müller, James C. Mullikin, Ngoc Nguyen, Gabriele Nordsiek, Gerald Nyakatura, Christopher N. O’Dell, Geoffery Okwuonu, Sophie Palmer, Richard Pandian, David Parker, Julia Parrish, Shiran Pasternak, Dina Patel, Alex V. Pearce, Danita M. Pearson, Sarah E. Pelan, Lesette Perez, Keith M. Porter, Yvonne Ramsey, Kathrin Reichwald, Susan Rhodes, Kerry A. Ridler, David Schlessinger, Mary G. Schueler, Harminder K. Sehra, Charles Shaw-Smith, Hua Shen, Elizabeth M. Sheridan, Ratna Shownkeen, Carl D. Skuce, Michelle L. Smith, Elizabeth C. Sotheran, Helen E. Steingruber, Charles A. Steward, Roy Storey, R. Mark Swann, David Swarbreck, Paul E. Tabor, Stefan Taudien, Tineace Taylor, Brian Teague, Karen Thomas, Andrea Thorpe, Kirsten Timms, Alan Tracey, Steve Trevanion, Anthony C. Tromans, Michele d’Urso, Daniel Verduzco, Donna Villasana, Lenee Waldron, Melanie Wall, Qiaoyan Wang, James Warren, Georgina L. Warry, Xuehong Wei, Anthony West, Siobhan L. Whitehead, Mathew N. Whiteley, Jane E. Wilkinson, David L. Willey, Gabrielle Williams, Leanne Williams, Angela Williamson, Helen Williamson, Laurens Wilming, Rebecca L. Woodmansey, Paul W. Wray, Jennifer Yen, Jingkun Zhang, Jianling Zhou, Huda Zoghbi, Sara Zorilla, David Buck, Richard Reinhardt, Annemarie Poustka, André Rosenthal, Hans Lehrach, Alfons Meindl, Patrick J. Minx, LaDeana W. Hillier, Huntington F. Willard, Richard K. Wilson, Robert H. Waterston, Catherine M. Rice, Mark Vaudin, Alan Coulson, David L. Nelson, George Weinstock, John E. Sulston, Richard Durbin, Tim Hubbard, Richard A. Gibbs, Stephan Beck, Jane Rogers, David R. Bentley
Nature. Author manuscript; available in PMC 2009 Apr 5.
Published in final edited form as: Nature. 2005 Mar 17; 434(7031): 325–337. doi: 10.1038/nature03440
PMCID:
PMC2665286
AbstractArticlePDF–1.0M
10.
Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia.
B. K. Saha, S. K. Curtis, L. B. Vogler, M. Vihinen
Mol Med. 1997 Jul; 3(7): 477–485.
PMCID:
PMC2230218
SummaryPage BrowsePDF–1.6M
11.
Induction of Immunoglobulin Heavy-Chain Transcription through the Transcription Factor Bright Requires TFII-I
Jaya Rajaiya, Jamee C. Nixon, Neil Ayers, Zana P. Desgranges, Ananda L. Roy, Carol F. Webb
Mol Cell Biol. 2006 Jun; 26(12): 4758–4768. doi: 10.1128/MCB.02009-05
PMCID:
PMC1489113
AbstractArticlePDF–355K
12.
Mutations in btk in patients with presumed X-linked agammaglobulinemia.
M E Conley, D Mathias, J Treadaway, Y Minegishi, J Rohrer
Am J Hum Genet. 1998 May; 62(5): 1034–1043. doi: 10.1086/301828
PMCID:
PMC1377085
SummaryPDF–1.3M
13.
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
M Hyvönen, M Saraste
EMBO J. 1997 Jun 15; 16(12): 3396–3404. doi: 10.1093/emboj/16.12.3396
PMCID:
PMC1169965
SummaryPDF–595K
14.
A new point mutation involving a highly conserved leucine in the Btk SH2 domain in a family with X linked agammaglobulinaemia.
Y Ohashi, S Tsuchiya, T Konno
J Med Genet. 1995 Jan; 32(1): 77–78. doi: 10.1136/jmg.32.1.77
PMCID:
PMC1050193
SummaryPage BrowsePDF–568K
15.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
16.
A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation
Shuling Guo, Gregory Z. Ferl, Rajendar Deora, Mireille Riedinger, Sheng Yin, James L. Kerwin, Joseph A. Loo, Owen N. Witte
Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39): 14180–14185. Published online 2004 Sep 16. doi: 10.1073/pnas.0405878101
PMCID:
PMC521099
AbstractArticlePDF–620K
17.
BTKbase, mutation database for X-linked agammaglobulinemia (XLA)
M Vihinen, B H Belohradsky, R N Haire, E Holinski-Feder, S P Kwan, I Lappalainen, H Lehväslaiho, T Lester, A Meindl, H D Ochs, J Ollila, I Vorechovsky, M Weiss, C I Smith
Nucleic Acids Res. 1997 Jan 1; 25(1): 166–171. doi: 10.1093/nar/25.1.166
PMCID:
PMC146405
SummaryPDF–90K
18.
BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
M Vihinen, T Iwata, C Kinnon, S P Kwan, H D Ochs, I Vorechovský, C I Smith
Nucleic Acids Res. 1996 Jan 1; 24(1): 160–165. doi: 10.1093/nar/24.1.160
PMCID:
PMC145577
SummaryPDF–91K
19.
PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization
Shin W. Kang, Matthew I. Wahl, Julia Chu, Jiro Kitaura, Yuko Kawakami, Roberta M. Kato, Ruby Tabuchi, Alexander Tarakhovsky, Toshiaki Kawakami, Christoph W. Turck, Owen N. Witte, David J. Rawlings
EMBO J. 2001 Oct 15; 20(20): 5692–5702. doi: 10.1093/emboj/20.20.5692
PMCID:
PMC125669
AbstractArticlePDF–369K
20.
Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.
M Vihinen, D Vetrie, H S Maniar, H D Ochs, Q Zhu, I Vorechovský, A D Webster, L D Notarangelo, L Nilsson, J M Sowadski, et al.
Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12803–12807. doi: 10.1073/pnas.91.26.12803
PMCID:
PMC45528
SummaryPage BrowsePDF–1.6M

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