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Select item 110403711.

Disruption of Super‐Enhancers in Activated Pancreatic Stellate Cells Facilitates Chemotherapy and Immunotherapy in Pancreatic Cancer

Yazhou Wang, Kai Chen, Gang Liu, Chong Du, Zhaoxia Cheng, Dan Wei, Fenfen Li, Chen Li, Yinmo Yang, Ying Zhao, Guangjun Nie

Adv Sci (Weinh) 2024 Apr; 11(16): 2308637. Published online 2024 Feb 28. doi: 10.1002/advs.202308637

PMCID:: PMC11040371

Abstract Article PDF–25M

Select item 109916672.

Selective BET-bromodomain inhibition by JQ1 suppresses dendritic cell maturation and antigen-specific T-cell responses

Niklas Remke, Savita Bisht, Sebastian Oberbeck, Jens Nolting, Peter Brossart

Cancer Immunol Immunother. 2021 Jan; 70(1): 107–121. Published online 2020 Jul 10. doi: 10.1007/s00262-020-02665-x

PMCID:: PMC10991667

Abstract Article PDF–2.1M

Select item 108997903.

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Andrew D Huber, Shyaron Poudel, Jing Wu, Darcie J Miller, Wenwei Lin, Lei Yang, Monicah N Bwayi, Mary Ashley Rimmer, Rebecca R Florke Gee, Jayaraman Seetharaman, Sergio C Chai, Taosheng Chen

Nucleic Acids Res. 2024 Feb 28; 52(4): 1661–1676. Published online 2023 Dec 12. doi: 10.1093/nar/gkad1175

PMCID:: PMC10899790

Abstract Article PDF–2.4M

Select item 105358024.

BET Inhibitor JQ1 Attenuates Feline Leukemia Virus DNA, Provirus, and Antigen Production in Domestic Cat Cell Lines

Garrick M. Moll, Cheryl L. Swenson, Vilma Yuzbasiyan-Gurkan

Viruses. 2023 Sep; 15(9): 1853. Published online 2023 Aug 31. doi: 10.3390/v15091853

PMCID:: PMC10535802

Abstract Article PDF–1.2M

Select item 103866035.

Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort, Ian M. Adcock

Respir Res. 2023; 24: 193. Published online 2023 Jul 29. doi: 10.1186/s12931-023-02499-y

PMCID:: PMC10386603

Abstract Article PDF–2.1M

Select item 99909076.

The Epigenetic Regulator BRD4 is Required for Myofibroblast Differentiation of Knee Fibroblasts

Amel Dudakovic, Banu Bayram, Jacob W. Bettencourt, Afton K. Limberg, M. Lizeth Galvan, Margarita E Carrasco, Britta Stans, Roman Thaler, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Andre J. van Wijnen, Matthew P. Abdel

J Cell Biochem. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: J Cell Biochem. 2023 Feb; 124(2): 320–334. Published online 2023 Jan 17. doi: 10.1002/jcb.30368

PMCID:: PMC9990907

Abstract Article PDF–2.6M

Select item 91739737.

Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer

Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson, Devin C. Koestler

BMC Cancer. 2022; 22: 627. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09690-2

PMCID:: PMC9173973

Abstract Article PDF–4.9M

Select item 90537888.

Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells

Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai

PLoS One. 2022; 17(4): e0266966. Published online 2022 Apr 29. doi: 10.1371/journal.pone.0266966

PMCID:: PMC9053788

Abstract Article PDF–4.3M

Select item 89284849.

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

Nathaniel J. Henning, Andrew G. Manford, Jessica N. Spradlin, Scott M. Brittain, Erika Zhang, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Michael Rape, Daniel K. Nomura

J Am Chem Soc. Author manuscript; available in PMC 2022 Jul 19.

Published in final edited form as: J Am Chem Soc. 2022 Jan 19; 144(2): 701–708. Published online 2022 Jan 7. doi: 10.1021/jacs.1c03980

Correction in:: J Am Chem Soc. 2023 Sep 14

PMCID:: PMC8928484

Abstract Article PDF–673K

Select item 882672010.

BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis

Tong Hua, Haowei Wang, Xiaoyi Fan, Ni An, Jian Li, Honghao Song, Erliang Kong, Yongchang Li, Hongbin Yuan

Front Immunol. 2022; 13: 837977. Published online 2022 Jan 26. doi: 10.3389/fimmu.2022.837977

PMCID:: PMC8826720

Abstract Article PDF–5.7M

Select item 868622211.

Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators

Haitao Sun, Tianzhu Yu, Xin Li, Yangyang Lei, Jianke Li, Xiuhui Wang, Peike Peng, Dalong Ni, Xiaolin Wang, Yu Luo

J Nanobiotechnology. 2021; 19: 433. Published online 2021 Dec 20. doi: 10.1186/s12951-021-01197-5

PMCID:: PMC8686222

Abstract Article PDF–14M

Select item 867132312.

JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

CJ Babigian, HJ Wiedner, C Wahlestedt, GC Sartor

Behav Brain Res. Author manuscript; available in PMC 2023 Feb 10.

Published in final edited form as: Behav Brain Res. 2022 Feb 10; 418: 113644. Published online 2021 Oct 28. doi: 10.1016/j.bbr.2021.113644

PMCID:: PMC8671323

Abstract Article PDF–247K

Select item 857944913.

Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer

Amjad Ali, Jasmin Shafarin, Hema Unnikannan, Nour Al-Jabi, Rola Abu Jabal, Khuloud Bajbouj, Jibran Sualeh Muhammad, Mawieh Hamad

Int J Biol Sci. 2021; 17(15): 4474–4492. Published online 2021 Oct 25. doi: 10.7150/ijbs.62236

PMCID:: PMC8579449

Abstract Article PDF–3.4M

Select item 855634014.

BET protein inhibition evidently enhances sensitivity to PI3K/mTOR dual inhibition in intrahepatic cholangiocarcinoma

Xiaolong Miao, Chen Liu, Yuancong Jiang, Yao Wang, Deqiang Kong, Zelai Wu, Xinyi Wang, Rui Tian, Xing Yu, Xuhang Zhu, Weihua Gong

Cell Death Dis. 2021 Nov; 12(11): 1020. Published online 2021 Oct 29. doi: 10.1038/s41419-021-04305-3

PMCID:: PMC8556340

Abstract Article PDF–4.7M

Select item 854132715.

The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation

Ayaka Washizaki, Megumi Murata, Yohei Seki, Masayuki Kikumori, Yinpui Tang, Weikeat Tan, Nadita P. Wardani, Kazuhiro Irie, Hirofumi Akari

Viruses. 2021 Oct; 13(10): 2037. Published online 2021 Oct 9. doi: 10.3390/v13102037

PMCID:: PMC8541327

Abstract Article PDF–3.8M

Select item 853114616.

BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma

Lin Xia, Jun-yi Liu, Zao-zao Zheng, Yu-jie Chen, Jian-cheng Ding, Ya-hong Hu, Guo-sheng Hu, Ning-shao Xia, Wen Liu

Mol Ther. 2021 Oct 6; 29(10): 3011–3026. Published online 2021 May 29. doi: 10.1016/j.ymthe.2021.05.019

PMCID:: PMC8531146

Abstract Article PDF–6.5M

Select item 848621517.

Bromodomain‐containing protein 4 inhibitor JQ1 promotes melanoma cell apoptosis by regulating mitochondrial dynamics

Liyuan Li, Yan Meng, Xiaolin Wu, Jiajing Li, Yuxin Sun

Cancer Sci. 2021 Oct; 112(10): 4013–4025. Published online 2021 Aug 8. doi: 10.1111/cas.15061

PMCID:: PMC8486215

Abstract Article PDF–1.8M

Select item 847481018.

Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma

Matthew J. Kling, Connor N. Griggs, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi

BMC Cancer. 2021; 21: 1061. Published online 2021 Sep 26. doi: 10.1186/s12885-021-08782-9

PMCID:: PMC8474810

Abstract Article PDF–2.5M

Select item 844640819.

Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance

Noushin Miralaei, Ahmad Majd, Kamran Ghaedi, Maryam Peymani, Masoomeh Safaei

Cancer Med. 2021 Sep; 10(18): 6428–6441. Published online 2021 Aug 1. doi: 10.1002/cam4.4161

PMCID:: PMC8446408

Abstract Article PDF–1.8M

Select item 842775620.

Brd4 Regulates the Homeostasis of CD8⁺ T-Lymphocytes and Their Proliferation in Response to Antigen Stimulation

Zhilin Peng, Yiwen Zhang, Xiancai Ma, Mo Zhou, Shiyu Wu, Zheng Song, Yaochang Yuan, Yingshi Chen, Yuzhuang Li, Guanwen Wang, Feng Huang, Yidan Qiao, Baijing Xia, Weiwei Liu, Jun Liu, Xu Zhang, Xin He, Ting Pan, Hanshi Xu, Hui Zhang

Front Immunol. 2021; 12: 728082. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.728082