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Select item 98719361.

Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice

Eleonora Daini, Eleonora Vandini, Martina Bodria, Wenjie Liao, Carlo Baraldi, Valentina Secco, Alessandra Ottani, Michele Zoli, Daniela Giuliani, Antonietta Vilella

Front Immunol. 2022; 13: 1082036. Published online 2023 Jan 10. doi: 10.3389/fimmu.2022.1082036

PMCID:: PMC9871936

Abstract Article PDF–7.9M

Select item 98702942.

Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling

Yingjin Qiao, Pei Wang, Mingyang Chang, Bohan Chen, Yan Ge, Deepak K. Malhotra, Lance D. Dworkin, Rujun Gong

Clin Sci (Lond) Author manuscript; available in PMC 2023 Jan 23.

Published in final edited form as: Clin Sci (Lond). 2020 Apr 17; 134(7): 695–710. doi: 10.1042/CS20200016

PMCID:: PMC9870294

Abstract Article PDF–1.6M

Select item 85639583.

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

Nicolas A. Heyder, Gunnar Kleinau, David Speck, Andrea Schmidt, Sarah Paisdzior, Michal Szczepek, Brian Bauer, Anja Koch, Monique Gallandi, Dennis Kwiatkowski, Jörg Bürger, Thorsten Mielke, Annette G. Beck-Sickinger, Peter W. Hildebrand, Christian M. T. Spahn, Daniel Hilger, Magdalena Schacherl, Heike Biebermann, Tarek Hilal, Peter Kühnen, Brian K. Kobilka, Patrick Scheerer

Cell Res. 2021 Nov; 31(11): 1176–1189. Published online 2021 Sep 24. doi: 10.1038/s41422-021-00569-8

PMCID:: PMC8563958

Abstract Article PDF–5.0M

Select item 83325234.

Predicting Brain Tumor Histology: Change of Effective Atomic Number with Contrast Enhancement

Richard E. Latchaw, J. Thomas Payne, Ruth B. Loewenson

AJNR Am J Neuroradiol. 1980 Jul-Aug; 1(4): 289-94. doi: 10.1093/oxfordjournals.jbchem.a131303

PMCID:: PMC8332523

Summary PDF–2.9M

Select item 76769695.

Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

Siming Fu, Xu Luo, Xuan Wu, Tongyu Zhang, Linggui Gu, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie

Oxid Med Cell Longev. 2020; 2020: 8864100. Published online 2020 Nov 12. doi: 10.1155/2020/8864100

PMCID:: PMC7676969

Abstract Article PDF–2.5M

Select item 68162066.

NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie

J Neuroinflammation. 2019; 16: 192. Published online 2019 Oct 28. doi: 10.1186/s12974-019-1591-4

PMCID:: PMC6816206

Abstract Article PDF–4.8M

Select item 67727457.

Antagonism of the Melanocortin System Reduces Cold and Mechanical Allodynia in Mononeuropathic Rats

Dorien H. Vrinten, Willem Hendrik Gispen, Gerbrand J. Groen, Roger A. H. Adan

J Neurosci. 2000 Nov 1; 20(21): 8131–8137. doi: 10.1523/JNEUROSCI.20-21-08131.2000

PMCID:: PMC6772745

Abstract Article PDF–192K

Select item 66898988.

A tumor-targeted immune checkpoint blocker

Yuhan Zhang, Changming Fang, Rongsheng E. Wang, Ying Wang, Hui Guo, Chao Guo, Lijun Zhao, Shuhong Li, Xia Li, Peter G. Schultz, Yu J. Cao, Feng Wang

Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32): 15889–15894. Published online 2019 Jul 22. doi: 10.1073/pnas.1905646116

PMCID:: PMC6689898

Abstract Article PDF–993K

Select item 59993999.

Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation

Yang Zhou, Saghar Mowlazadeh Haghighi, Ioanna Zoi, Jonathon R. Sawyer, Victor J. Hruby, Minying Cai

J Med Chem. Author manuscript; available in PMC 2018 Jun 13.

Published in final edited form as: J Med Chem. 2017 Nov 22; 60(22): 9320–9329. Published online 2017 Nov 13. doi: 10.1021/acs.jmedchem.7b01295

Correction in:: J Med Chem. 2018 Sep 25

PMCID:: PMC5999399

Abstract Article PDF–714K

Select item 563969410.

A Macrocyclic Agouti-Related Protein/[Nle4, DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Sub-nanomolar Melanocortin Receptor Ligands

Mark D. Ericson, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano

J Med Chem. Author manuscript; available in PMC 2018 Jan 26.

Published in final edited form as: J Med Chem. 2017 Jan 26; 60(2): 805–813. Published online 2017 Jan 17. doi: 10.1021/acs.jmedchem.6b01707

PMCID:: PMC5639694

Abstract Article PDF–464K

Select item 559663611.

Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors

Aleksandar Todorovic, Mark D. Ericson, Ryan D. Palusak, Nicholas B. Sorensen, Michael S. Wood, Zhimin Xiang, Carrie Haskell-Luevano

ACS Chem Neurosci. Author manuscript; available in PMC 2017 Sep 13.

Published in final edited form as: ACS Chem Neurosci. 2016 Jul 20; 7(7): 984–994. Published online 2016 May 17. doi: 10.1021/acschemneuro.6b00098

PMCID:: PMC5596636

Abstract Article PDF–610K

Select item 492878312.

[Nle⁴, D-Phe⁷]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype

Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Carla Caruso, Mercedes Lasaga

PLoS One. 2016; 11(6): e0158564. Published online 2016 Jun 30. doi: 10.1371/journal.pone.0158564

PMCID:: PMC4928783

Abstract Article PDF–9.4M

Select item 483950913.

Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole

Meera E Modi, Kiyoshi Inoue, Catherine E Barrett, Kara A Kittelberger, Daniel G Smith, Rainer Landgraf, Larry J Young

Neuropsychopharmacology. 2015 Jul; 40(8): 1856–1865. Prepublished online 2015 Feb 5. Published online 2015 Mar 4. doi: 10.1038/npp.2015.35

PMCID:: PMC4839509

Abstract Article PDF–559K

Select item 447528514.

α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines

Franco Capsoni, Anna Maria Ongari, Caterina Lonati, Riccardo Accetta, Stefano Gatti, Anna Catania

BMC Musculoskelet Disord. 2015; 16: 154. Published online 2015 Jun 21. doi: 10.1186/s12891-015-0615-1

PMCID:: PMC4475285

Abstract Article PDF–601K

Select item 399498615.

Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands

Kimberley A. Beaumont, Darren J. Smit, Yan Yan Liu, Eric Chai, Mira P. Patel, Glenn L. Millhauser, Jennifer J. Smith, Paul F. Alewood, Richard A. Sturm

Pigment Cell Melanoma Res. Author manuscript; available in PMC 2014 Apr 22.

Published in final edited form as: Pigment Cell Melanoma Res. 2012 May; 25(3): 370–374. Published online 2012 Mar 19. doi: 10.1111/j.1755-148X.2012.00990.x

PMCID:: PMC3994986

Abstract Article PDF–1.8M

Select item 374545816.

α-MSH Analogue Attenuates Blood Pressure Elevation in DOCA-Salt Hypertensive Mice

Petteri Rinne, Anna-Maija Penttinen, Wendy Nordlund, Markku Ahotupa, Eriika Savontaus

PLoS One. 2013; 8(8): e72857. Published online 2013 Aug 16. doi: 10.1371/journal.pone.0072857

PMCID:: PMC3745458

Abstract Article PDF–1.0M

Select item 356335317.

Synthesis and Characterization of a Melanoma-Targeted Fluorescence Imaging Probe by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand

Narges K Tafreshi, Xuan Huang, Valerie E Moberg, Natalie M. Barkey, Vernon K. Sondak, Haibin Tian, David L Morse, Josef Vagner

Bioconjug Chem. Author manuscript; available in PMC 2013 Dec 19.

Published in final edited form as: Bioconjug Chem. 2012 Dec 19; 23(12): 2451–2459. Published online 2012 Nov 27. doi: 10.1021/bc300549s

PMCID:: PMC3563353

Abstract Article PDF–1.1M

Select item 353803618.

Synthesis and Evaluation of Bivalent NDP-a-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R)

Heather L. Handl, Rajesh Sankaranarayanan, Jatinder S. Josan, Josef Vagner, Eugene A. Mash, Robert J. Gillies, Victor J. Hruby

Bioconjug Chem. Author manuscript; available in PMC 2013 Jan 5.

Published in final edited form as: Bioconjug Chem. 2007 Jul-Aug; 18(4): 1101–1109. Published online 2007 Jun 26. doi: 10.1021/bc0603642

PMCID:: PMC3538036

Abstract Article PDF–1.1M

Select item 328255319.

Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling

Biaoxin Chai, Ji-Yao Li, Weizhen Zhang, Xiaobin Wu, Chao Zhang, Michael W. Mulholland

Peptides. Author manuscript; available in PMC 2012 Feb 20.

Published in final edited form as: Peptides. 2010 Oct; 31(10): 1888–1893. Published online 2010 Jul 31. doi: 10.1016/j.peptides.2010.06.028

PMCID:: PMC3282553

Abstract Article PDF–1.0M

Select item 317665420.

Melanocortin 4 Receptor Activation Protects Against Testicular Ischemia-Reperfusion Injury by Triggering the Cholinergic Antiinflammatory Pathway

Letteria Minutoli, Alessandra Bitto, Francesco Squadrito, Natasha Irrera, Mariagrazia Rinaldi, Piero Antonio Nicotina, Salvatore Arena, Carlo Magno, Herbert Marini, Luca Spaccapelo, Alessandra Ottani, Daniela Giuliani, Carmelo Romeo, Salvatore Guarini, Pietro Antonuccio, Domenica Altavilla

Endocrinology. 2011 Oct; 152(10): 3852–3861. Published online 2011 Aug 9. doi: 10.1210/en.2011-1016

PMCID:: PMC3176654

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