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Select item 70463051.

Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway

Jin Zhou, Yuan‐yuan Jiang, Huan Chen, Yi‐chao Wu, Li Zhang

Cell Prolif. 2020 Feb; 53(2): e12739. Published online 2019 Dec 9. doi: 10.1111/cpr.12739

PMCID:: PMC7046305

Article PDF–3.0M

Select item 70463042.

SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway

Jun Xu, Yujie Deng, Yi Wang, Xiaofang Sun, Shuqin Chen, Guoxiang Fu

Cell Prolif. 2020 Feb; 53(2): e12738. Published online 2020 Jan 19. doi: 10.1111/cpr.12738

PMCID:: PMC7046304

Article PDF–3.4M

Select item 69424303.

Tumor‐associated macrophages secrete CC‐chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer

Dongbo Li, Hongfei Ji, Xingjian Niu, Lei Yin, Yiran Wang, Yucui Gu, Jinlu Wang, Xiaoping Zhou, Han Zhang, Qingyuan Zhang

Cancer Sci. 2020 Jan; 111(1): 47–58. Published online 2019 Dec 19. doi: 10.1111/cas.14230

PMCID:: PMC6942430

Article PDF–1.8M

Select item 454814.

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

M I Chiu, H Katz, V Berlin

Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12574–12578. doi: 10.1073/pnas.91.26.12574

PMCID:: PMC45481

Summary Page Browse PDF–1.4M

Select item 418245.

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

J Chen, X F Zheng, E J Brown, S L Schreiber

Proc Natl Acad Sci U S A. 1995 May 23; 92(11): 4947–4951. doi: 10.1073/pnas.92.11.4947

PMCID:: PMC41824

Summary Page Browse PDF–1.4M

Select item 69846036.

The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability

Julia A. Thayer, Ola Awad, Nivedita Hegdekar, Chinmoy Sarkar, Henok Tesfay, Cameran Burt, Xianmin Zeng, Ricardo A. Feldman, Marta M. Lipinski

Autophagy. 2020; 16(1): 140–153. Published online 2019 Apr 7. doi: 10.1080/15548627.2019.1598754

PMCID:: PMC6984603

Article PDF–3.4M

Select item 68513937.

Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

Sara Baldassari, Théo Ribierre, Elise Marsan, Homa Adle-Biassette, Sarah Ferrand-Sorbets, Christine Bulteau, Nathalie Dorison, Martine Fohlen, Marc Polivka, Sarah Weckhuysen, Georg Dorfmüller, Mathilde Chipaux, Stéphanie Baulac

Acta Neuropathol. 2019; 138(6): 885–900. Published online 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

PMCID:: PMC6851393

Article PDF–2.6M

Select item 68317458.

Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages

Jiezhi Dai, Chaoyin Jiang, Hua Chen, Yimin Chai

Front Pharmacol. 2019; 10: 1292. Published online 2019 Oct 30. doi: 10.3389/fphar.2019.01292

PMCID:: PMC6831745

Article PDF–3.3M

Select item 66607009.

A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing

Ye Cao, Mari J. Tokita, Edward S. Chen, Rajarshi Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth Gorman, Federica Gibellini, Patricia A. Ward, Alicia Braxton, Xia Wang, Linyan Meng, Rui Xiao, Weimin Bi, Fan Xia, Christine M. Eng, Yaping Yang, Tomasz Gambin, Chad Shaw, Pengfei Liu, Pawel Stankiewicz

Genome Med. 2019; 11: 48. Published online 2019 Jul 26. doi: 10.1186/s13073-019-0658-2

PMCID:: PMC6660700

Article PDF–980K

Select item 646188410.

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

Lambert C. J. Dorssers, Ad J. M. Gillis, Hans Stoop, Ronald van Marion, Marleen M. Nieboer, Job van Riet, Harmen J. G. van de Werken, J. Wolter Oosterhuis, Jeroen de Ridder, Leendert H. J. Looijenga

Br J Cancer. 2019 Feb 19; 120(4): 444–452. Published online 2019 Feb 11. doi: 10.1038/s41416-019-0381-1

PMCID:: PMC6461884

Article PDF–1.5M

Select item 643136111.

Epicatechin Gallate Protects HBMVECs from Ischemia/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization

Bing Fu, Qinghong Zeng, Zhaoting Zhang, Mingyue Qian, Jiechun Chen, Wanli Dong, Min Li

Oxid Med Cell Longev. 2019; 2019: 7824684. Published online 2019 Mar 6. doi: 10.1155/2019/7824684

PMCID:: PMC6431361

Article PDF–2.6M

Select item 628650412.

Celastrus orbiculatus extracts induce apoptosis in mTOR-overexpressed human hepatocellular carcinoma HepG2 cells

Yayun Qian, Ting Yang, Xueyu Zhao, Yan Yan, Wenyuan Li, Chuanci Fang, Jingjing Hou, Li Tao, Yanqing Liu

BMC Complement Altern Med. 2018; 18: 328. Published online 2018 Dec 7. doi: 10.1186/s12906-018-2397-0

PMCID:: PMC6286504

Article PDF–4.3M

Select item 617101913.

Inhibition of Phospholipase D1 mRNA Expression Slows Down the Proliferation Rate of Prostate Cancer Cells That Have Transited to Androgen Independence

Wu Zhou, Keqing Shi, Lili Ji, Ruihao Wu, Yuehui Chen, Hongxiang Tu, Beibei Zhou, Zhongyong Wang, Meijuan Zhang

J Cancer. 2018; 9(19): 3620–3625. Published online 2018 Sep 8. doi: 10.7150/jca.26689

PMCID:: PMC6171019

Article PDF–767K

Select item 584447614.

Complete mutational spectrum of the autophagy interactome: a novel class of tumor suppressor genes in myeloid neoplasms

Valeria Visconte, Bartlomiej Przychodzen, Yingchun Han, Steffan T. Nawrocki, Swapna Thota, Kevin R. Kelly, Bhumika J. Patel, Cassandra Hirsch, Anjali S. Advani, Hetty E. Carraway, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Jennifer S. Carew

Leukemia. Author manuscript; available in PMC 2018 Mar 9.

Published in final edited form as: Leukemia. 2017 Feb; 31(2): 505–510. Published online 2016 Oct 24. doi: 10.1038/leu.2016.295

PMCID:: PMC5844476

Article PDF–424K

Select item 584399715.

Sequencing of circulating tumor DNA for dynamic monitoring of gene mutations in advanced non-small cell lung cancer

Ruilian Xu, Guolin Zhong, Tanxiao Huang, Wan He, Cheng Kong, Xiaoni Zhang, Ying Wang, Ming Liu, Mingyan Xu, Shifu Chen

Oncol Lett. 2018 Mar; 15(3): 3726–3734. Published online 2018 Jan 16. doi: 10.3892/ol.2018.7808

PMCID:: PMC5843997

Article PDF–1.5M

Select item 575749516.

miR-99a-5p acts as tumor suppressor via targeting to mTOR and enhances RAD001-induced apoptosis in human urinary bladder urothelial carcinoma cells

Te-Fu Tsai, Ji-Fan Lin, Kuang-Yu Chou, Yi-Chia Lin, Hung-En Chen, Thomas I-Sheng Hwang

Onco Targets Ther. 2018; 11: 239–252. Published online 2018 Jan 4. doi: 10.2147/OTT.S114276

PMCID:: PMC5757495

Article PDF–4.1M

Select item 554873217.

Prognostic value of a 25-gene assay in patients with gastric cancer after curative resection

Xiaohong Wang, Yiqiang Liu, Zhaojian Niu, Runjia Fu, Yongning Jia, Li Zhang, Duanfang Shao, Hong Du, Ying Hu, Xiaofang Xing, Xiaojing Cheng, Lin Li, Ting Guo, Ziyu Li, Qunsheng Ji, Lianhai Zhang, Jiafu Ji

Sci Rep. 2017; 7: 7515. Published online 2017 Aug 8. doi: 10.1038/s41598-017-07604-y

PMCID:: PMC5548732

Article PDF–2.9M

Select item 553237118.

MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus

Kyousuke Kobayashi, Fumiko Suemasa, Hiroshi Sagara, Shinya Nakamura, Yasushi Ino, Kazuyoshi Kobayashi, Hiroaki Hiramatsu, Takeshi Haraguchi, Kazuo Kurokawa, Tomoki Todo, Akihiko Nakano, Hideo Iba

Sci Rep. 2017; 7: 6650. Published online 2017 Jul 27. doi: 10.1038/s41598-017-06754-3

PMCID:: PMC5532371

Article PDF–4.4M

Select item 547706819.

Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization

Tae Kwann Park, Si Hyung Lee, Jun Sub Choi, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Heuiran Lee, Steven Hyun Seung Lee, Keerang Park

Mol Ther Nucleic Acids. 2017 Sep 15; 8: 26–35. Published online 2017 Jun 1. doi: 10.1016/j.omtn.2017.05.012

PMCID:: PMC5477068

Article PDF–2.4M

Select item 542035520.

Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability

Katrina Tatton-Brown, Chey Loveday, Shawn Yost, Matthew Clarke, Emma Ramsay, Anna Zachariou, Anna Elliott, Harriet Wylie, Anna Ardissone, Olaf Rittinger, Fiona Stewart, I. Karen Temple, Trevor Cole, Childhood Overgrowth Collaboration, Shazia Mahamdallie, Sheila Seal, Elise Ruark, Nazneen Rahman

Am J Hum Genet. 2017 May 4; 100(5): 725–736. Published online 2017 May 4. doi: 10.1016/j.ajhg.2017.03.010