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Select item 69714911.

Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels

Evan P. Taddeo, Nour Alsabeeh, Siyouneh Baghdasarian, Jakob D. Wikstrom, Eleni Ritou, Samuel Sereda, Karel Erion, Jin Li, Linsey Stiles, Muhamad Abdulla, Zachary Swanson, Joshua J. Wilhelm, Melena D. Bellin, Richard G. Kibbey, Marc Liesa, Orian S. Shirihai

Diabetes. 2020 Feb; 69(2): 131–145. Published online 2019 Nov 18. doi: 10.2337/db19-0379

PMCID:: PMC6971491

Abstract Article PDF–2.1M

Select item 59375252.

Genetic evidence that carbohydrate-stimulated insulin secretion leads to obesity

Christina M. Astley, Jennifer N. Todd, Rany M. Salem, Sailaja Vedantam, Cara B. Ebbeling, Paul L. Huang, David S. Ludwig, Joel N. Hirschhorn, Jose C. Florez

Clin Chem. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Clin Chem. 2018 Jan; 64(1): 192–200. doi: 10.1373/clinchem.2017.280727

PMCID:: PMC5937525

Abstract Article PDF–258K

Select item 49766253.

Inactivation of the adrenergic receptor β₂ disrupts glucose homeostasis in mice

Gustavo W Fernandes, Cintia B Ueta, Tatiane L Fonseca, Cecilia H A Gouveia, Carmen L Lancellotti, Patrícia C Brum, Marcelo A Christoffolete, Antonio C Bianco, Miriam O Ribeiro

J Endocrinol. Author manuscript; available in PMC 2016 Aug 8.

Published in final edited form as: J Endocrinol. 2014 Jun; 221(3): 381–390. doi: 10.1530/JOE-13-0526

PMCID:: PMC4976625

Abstract Article PDF–652K

Select item 49381884.

Effect of Hypertriglyceridemia on Beta Cell Mass and Function in ApoC3 Transgenic Mice

Yun-Zi Liu, Xiaoyun Cheng, Ting Zhang, Sojin Lee, Jun Yamauchi, Xiangwei Xiao, George Gittes, Shen Qu, Chun-Lei Jiang, H. Henry Dong

J Biol Chem. 2016 Jul 8; 291(28): 14695–14705. Published online 2016 May 11. doi: 10.1074/jbc.M115.707885

PMCID:: PMC4938188

Abstract Article PDF–2.5M

Select item 45054715.

Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice

Virtu Calabuig-Navarro, Jun Yamauchi, Sojin Lee, Ting Zhang, Yun-Zi Liu, Kelsey Sadlek, Gina M. Coudriet, Jon D. Piganelli, Chun-Lei Jiang, Rita Miller, Mark Lowe, Hideyoshi Harashima, H. Henry Dong

J Biol Chem. 2015 Jun 19; 290(25): 15581–15594. Published online 2015 May 5. doi: 10.1074/jbc.M115.650994

PMCID:: PMC4505471

Abstract Article PDF–3.2M

Select item 43672366.

CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion

Hongzhi Zheng, Jingqi Fu, Peng Xue, Rui Zhao, Jian Dong, Dianxin Liu, Masayuki Yamamoto, Qingchun Tong, Weiping Teng, Weidong Qu, Qiang Zhang, Melvin E. Andersen, Jingbo Pi

Antioxid Redox Signal. 2015 Apr 1; 22(10): 819–831. doi: 10.1089/ars.2014.6017

PMCID:: PMC4367236

Abstract Article PDF–809K

Select item 40760917.

PPARδ activation attenuates hepatic steatosis in Ldlr^−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Lazar A. Bojic, Dawn E. Telford, Morgan D. Fullerton, Rebecca J. Ford, Brian G. Sutherland, Jane Y. Edwards, Cynthia G. Sawyez, Robert Gros, Bruce E. Kemp, Gregory R. Steinberg, Murray W. Huff

J Lipid Res. 2014 Jul; 55(7): 1254–1266. doi: 10.1194/jlr.M046037

PMCID:: PMC4076091

Abstract Article PDF–1.9M

Select item 35815028.

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose

Taku Fukuzawa, Masanori Fukazawa, Otoya Ueda, Hideaki Shimada, Aki Kito, Mami Kakefuda, Yosuke Kawase, Naoko A. Wada, Chisato Goto, Naoshi Fukushima, Kou-ichi Jishage, Kiyofumi Honda, George L. King, Yoshiki Kawabe

PLoS One. 2013; 8(2): e56681. Published online 2013 Feb 25. doi: 10.1371/journal.pone.0056681

PMCID:: PMC3581502

Abstract Article PDF–1.3M

Select item 27903199.

Hematopoietic cell specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high fat fed mice

Maziyar Saberi, Niels-Bjarne Woods, Carl de Luca, Simon Schenk, Juu Chin Lu, Gautam Bandyopadhyay, Inder M. Verma, Jerrold M. Olefsky

Cell Metab. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Cell Metab. 2009 Nov; 10(5): 419–429. doi: 10.1016/j.cmet.2009.09.006

PMCID:: PMC2790319

Abstract Article PDF–1.0M

Select item 275022810.

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance

Erin E. Mulvihill, Emma M. Allister, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Janet M. Markle, Robert A. Hegele, Murray W. Huff

Diabetes. 2009 Oct; 58(10): 2198–2210. Published online 2009 Jul 10. doi: 10.2337/db09-0634

PMCID:: PMC2750228

Abstract Article PDF–2.6M

Select item 50789311.

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Y Terauchi, K Iwamoto, H Tamemoto, K Komeda, C Ishii, Y Kanazawa, N Asanuma, T Aizawa, Y Akanuma, K Yasuda, T Kodama, K Tobe, Y Yazaki, T Kadowaki

J Clin Invest. 1997 Mar 1; 99(5): 861–866. doi: 10.1172/JCI119250

PMCID:: PMC507893

Summary PDF–388K

Select item 42515712.

Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.

S E Shoelson, K S Polonsky, A Zeidler, A H Rubenstein, H S Tager

J Clin Invest. 1984 May; 73(5): 1351–1358. doi: 10.1172/JCI111338

PMCID:: PMC425157

Summary Page Browse PDF–1.3M

Select item 42394013.

Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val----Leu) isolated from the pancreas.

H Sakura, Y Iwamoto, Y Sakamoto, T Kuzuya, H Hirata

J Clin Invest. 1986 Dec; 78(6): 1666–1672. doi: 10.1172/JCI112760

PMCID:: PMC423940

Summary Page Browse PDF–1.1M

Select item 42337314.

Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.

K Nanjo, T Sanke, M Miyano, K Okai, R Sowa, M Kondo, S Nishimura, K Iwo, K Miyamura, B D Given, et al.

J Clin Invest. 1986 Feb; 77(2): 514–519. doi: 10.1172/JCI112331

PMCID:: PMC423373

Summary Page Browse PDF–1.1M

Select item 29588915.

A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).

H Yano, N Kitano, M Morimoto, K S Polonsky, H Imura, Y Seino

J Clin Invest. 1992 Jun; 89(6): 1902–1907. doi: 10.1172/JCI115795

PMCID:: PMC295889

Summary Page Browse PDF–1.3M

Select item 854787016.

Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis

Ida Søgaard Larsen, Benjamin A. H. Jensen, Erica Bonazzi, Béatrice S. Y. Choi, Nanna Ny Kristensen, Esben Gjerløff Wedebye Schmidt, Annika Süenderhauf, Laurence Morin, Peter Bjarke Olsen, Lea Benedicte Skov Hansen, Torsten Schröder, Christian Sina, Benoît Chassaing, André Marette

Gut Microbes. 2021; 13(1): 1988836. Published online 2021 Oct 25. doi: 10.1080/19490976.2021.1988836

PMCID:: PMC8547870

Abstract Article PDF–4.4M

Select item 1088215517.

Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia

Harry B. Cutler, Søren Madsen, Stewart W.C. Masson, Kristen C. Cooke, Meg Potter, James G. Burchfield, Jacqueline Stöckli, Marin E. Nelson, Gregory J. Cooney, David E. James

Diabetes. 2024 Mar; 73(3): 359–373. Published online 2023 Sep 12. doi: 10.2337/db23-0035

PMCID:: PMC10882155

Abstract Article PDF–22M

Select item 1040344218.

Glucose-dependent inflammatory responses in obese compared to lean individuals

Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson

Endocrine. 2023; 81(3): 464–476. Published online 2023 Jul 3. doi: 10.1007/s12020-023-03433-4

PMCID:: PMC10403442

Abstract Article PDF–1.0M

Select item 997065919.

High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice

Jenna M. Frick, Olivia C. Eller, Rebecca M. Foright, Brittni M. Levasseur, Xiaofang Yang, Ruipeng Wang, Michelle K. Winter, Maura F. O’Neil, E. Matthew Morris, John P. Thyfault, Julie A. Christianson

Am J Physiol Regul Integr Comp Physiol. 2023 Mar 1; 324(3): R353–R367. Published online 2023 Jan 24. doi: 10.1152/ajpregu.00216.2022