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Items: 1 to 20 of 49

1.
Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin
Uttkarsh Ayyangar, Aneesh Karkhanis, Heather Tay, Aliya Farissa Binte Afandi, Oindrila Bhattacharjee, Lalitha KS, Sze Han Lee, James Chan, Srikala Raghavan
EMBO J. 2024 Apr; 43(7): 1113–1134. Published online 2024 Feb 28. doi: 10.1038/s44318-024-00039-y
PMCID:
PMC10987662
AbstractArticlePDF–12M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow
Michael Bonadonna, Sandro Altamura, Elisabeth Tybl, Gael Palais, Maria Qatato, Maria Polycarpou-Schwarz, Martin Schneider, Christina Kalk, Wibke Rüdiger, Alina Ertl, Natasha Anstee, Ruzhica Bogeska, Dominic Helm, Michael D. Milsom, Bruno Galy
Sci Adv. 2022 Oct; 8(40): eabq4469. Published online 2022 Oct 5. doi: 10.1126/sciadv.abq4469
PMCID:
PMC9534496
AbstractArticlePDF–6.0M
4.
Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy
James A. Votava, Shannon R. Reese, Kathryn M. Deck, Christopher P. Nizzi, Sheila A. Anderson, Arjang Djamali, Richard S. Eisenstein
Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F89–F103. Published online 2021 Nov 30. doi: 10.1152/ajprenal.00537.2020
PMCID:
PMC8742730
AbstractArticle
5.
Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis
Jin-Seon Yook, Mikyoung You, Jiyoung Kim, Ashley M. Toney, Rong Fan, Bhanwar Lal Puniya, Tomáš Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Okla, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Proc Natl Acad Sci U S A. 2021 Oct 5; 118(40): e2109186118. Published online 2021 Sep 30. doi: 10.1073/pnas.2109186118
PMCID:
PMC8501873
AbstractArticlePDF–2.7M
6.
Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases
Manik C. Ghosh, De-Liang Zhang, Wade H. Ollivierre, Audrey Noguchi, Danielle A. Springer, W. Marston Linehan, Tracey A. Rouault
Blood. 2021 May 6; 137(18): 2509–2519. Prepublished online 2020 Dec 17. doi: 10.1182/blood.2020009138
PMCID:
PMC8109019
AbstractArticle
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia
Manik C. Ghosh, De-Liang Zhang, Hayden Ollivierre, Michael A. Eckhaus, Tracey A. Rouault
J Clin Invest. 2018 Apr 2; 128(4): 1317–1325. Published online 2018 Feb 26. doi: 10.1172/JCI97684
PMCID:
PMC5873849
AbstractArticlePDF–5.0M
9.
Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines
Shida Zhou, Xinxing Du, Junxia Xie, Jun Wang
PLoS One. 2017; 12(7): e0180464. Published online 2017 Jul 3. doi: 10.1371/journal.pone.0180464
PMCID:
PMC5495437
AbstractArticlePDF–3.8M
10.
A drastic superoxide-dependent oxidative stress is prerequisite for the down-regulation of IRP1: Insights from studies on SOD1-deficient mice and macrophages treated with paraquat
Anna Milczarek, Rafał R. Starzyński, Agnieszka Styś, Aneta Jończy, Robert Staroń, Agnieszka Grzelak, Paweł Lipiński
PLoS One. 2017; 12(5): e0176800. Published online 2017 May 19. doi: 10.1371/journal.pone.0176800
PMCID:
PMC5438123
AbstractArticlePDF–14M
11.
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells
Takayoshi Yamauchi, Masaaki Nishiyama, Toshiro Moroishi, Atsuki Kawamura, Keiichi I. Nakayama
Mol Cell Biol. 2017 Apr 15; 37(8): e00470-16. Prepublished online 2017 Jan 9. Published online 2017 Mar 31. doi: 10.1128/MCB.00470-16
PMCID:
PMC5376637
AbstractArticlePDF–8.1M
12.
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Vinay Bulusu, Nicole Prior, Marteinn T. Snaebjornsson, Andreas Kuehne, Katharina F. Sonnen, Jana Kress, Frank Stein, Carsten Schultz, Uwe Sauer, Alexander Aulehla
Dev Cell. 2017 Feb 27; 40(4): 331–341.e4. doi: 10.1016/j.devcel.2017.01.015
PMCID:
PMC5337618
AbstractArticle
13.
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series
Caitlyn E. Bowman, Liang Zhao, Thomas Hartung, Michael J. Wolfgang
Mol Cell Biol. 2016 Aug 1; 36(15): 2089–2104. Prepublished online 2016 May 23. Published online 2016 Jul 14. doi: 10.1128/MCB.00166-16
PMCID:
PMC4946427
AbstractArticlePDF–3.4M
14.
IRON REGULATORY PROTEINS MEDIATE HOST RESISTANCE TO SALMONELLA INFECTION
Manfred Nairz, Dunja Ferring-Appel, Daniela Casarrubea, Thomas Sonnweber, Lydie Viatte, Andrea Schroll, David Haschka, Ferric C. Fang, Matthias W. Hentze, Guenter Weiss, Bruno Galy
Cell Host Microbe. Author manuscript; available in PMC 2016 Aug 12.
Published in final edited form as: Cell Host Microbe. 2015 Aug 12; 18(2): 254–261. Published online 2015 Jul 16. doi: 10.1016/j.chom.2015.06.017
PMCID:
PMC4666941
AbstractArticlePDF–525K
15.
Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins
Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault
Neurobiol Dis. Author manuscript; available in PMC 2016 Sep 1.
Published in final edited form as: Neurobiol Dis. 2015 Sep; 81: 66–75. Published online 2015 Mar 11. doi: 10.1016/j.nbd.2015.02.026
PMCID:
PMC4567523
AbstractArticlePDF–1010K
16.
Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria
Jacky Chung, Sheila A. Anderson, Babette Gwynn, Kathryn M. Deck, Michael J. Chen, Nathaniel B. Langer, George C. Shaw, Nicholas C. Huston, Leah F. Boyer, Sumon Datta, Prasad N. Paradkar, Liangtao Li, Zong Wei, Amy J. Lambert, Kenneth Sahr, Johannes G. Wittig, Wen Chen, Wange Lu, Bruno Galy, Thorsten M. Schlaeger, Matthias W. Hentze, Diane M. Ward, Jerry Kaplan, Richard S. Eisenstein, Luanne L. Peters, Barry H. Paw
J Biol Chem. 2014 Mar 14; 289(11): 7835–7843. Published online 2014 Feb 7. doi: 10.1074/jbc.M114.547778
Correction in:
J Biol Chem. 2014 May 16; 289(20): 13707.
PMCID:
PMC3953295
AbstractArticlePDF–1.4M
17.
Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease
Sanghamitra Bandyopadhyay, Catherine Cahill, Amelie Balleidier, Conan Huang, Debomoy K. Lahiri, Xudong Huang, Jack T. Rogers
PLoS One. 2013; 8(7): e65978. Published online 2013 Jul 31. doi: 10.1371/journal.pone.0065978
PMCID:
PMC3729844
AbstractArticlePDF–1.1M
18.
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
D. Casarrubea, L. Viatte, T. Hallas, A. Vasanthakumar, R. S. Eisenstein, K. Schümann, M. W. Hentze, B. Galy
J Mol Med (Berl) 2013; 91(7): 871–881. Published online 2013 Mar 1. doi: 10.1007/s00109-013-1008-2
PMCID:
PMC3695688
AbstractArticlePDF–824K
19.
The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
Sheila A. Anderson, Christopher P. Nizzi, Yuan-I Chang, Kathryn M. Deck, Paul J. Schmidt, Bruno Galy, Alisa Damnernsawad, Aimee T. Broman, Christina Kendziorski, Matthias W. Hentze, Mark D. Fleming, Jing Zhang, Richard S. Eisenstein
Cell Metab. Author manuscript; available in PMC 2014 Feb 5.
Published in final edited form as: Cell Metab. 2013 Feb 5; 17(2): 282–290. doi: 10.1016/j.cmet.2013.01.007
PMCID:
PMC3612289
AbstractArticlePDF–2.7M
20.
Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational De-repression of HIF2α
Manik C. Ghosh, De-Liang Zhang, Suh Young Jeong, Gennadiy Kovtunovych, Hayden Ollivierre-Wilson, Audrey Noguchi, Tiffany Tu, Thomas Senecal, Gabrielle Robinson, Daniel R. Crooks, Wing-Hang Tong, Kavitha Ramaswamy, Anamika Singh, Brian B. Graham, Rubin M. Tuder, Zu-Xi Yu, Michael Eckhaus, Jaekwon Lee, Danielle A. Springer, Tracey A. Rouault
Cell Metab. Author manuscript; available in PMC 2014 Feb 5.
Published in final edited form as: Cell Metab. 2013 Feb 5; 17(2): 271–281. doi: 10.1016/j.cmet.2012.12.016
PMCID:
PMC3569856
AbstractArticlePDF–4.9M

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