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Items: 1 to 20 of 87

1.
Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage
Ning Du, Boxiang Zhang, Yunfeng Zhang
Can Respir J. 2023; 2023: 4533504. Published online 2023 Jul 28. doi: 10.1155/2023/4533504
PMCID:
PMC10403328
AbstractArticlePDF–2.9M
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
Eva Monte-Serrano, Patricia Morejón-García, Ignacio Campillo-Marcos, Aurora Campos-Díaz, Elena Navarro-Carrasco, Pedro A. Lazo
Epigenetics Chromatin. 2023; 16: 18. Published online 2023 May 13. doi: 10.1186/s13072-023-00494-7
PMCID:
PMC10182654
AbstractArticlePDF–3.1M
4.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
5.
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons
Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson
J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888
PMCID:
PMC9978635
AbstractArticlePDF–10M
6.
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang, Lan Wang
Leukemia. 2023; 37(1): 164–177. Published online 2022 Nov 9. doi: 10.1038/s41375-022-01747-2
PMCID:
PMC9883169
AbstractArticlePDF–6.6M
7.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
8.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
9.
VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
JCI Insight. 2022 Oct 10; 7(19): e158755. Published online 2022 Oct 10. doi: 10.1172/jci.insight.158755
PMCID:
PMC9675470
AbstractArticlePDF–15M
10.
VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Erin E. Mulkearns-Hubert, Nicole Hajdari, Maria Dam Ferdinez, Justin L. Engel, Daniel J. Silver, Binzhang Shen, Wenhai Zhang, Christopher G. Hubert, Kelly Mitchell, Sajina Shakya, Shan-Chuan Zhao, Alborz Bejnood, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, Natasha Emmanuel
Cancer Res. 2022 Nov 2; 82(21): 4044–4057. Published online 2022 Sep 7. doi: 10.1158/0008-5472.CAN-21-4443
PMCID:
PMC9627132
AbstractArticlePDF–2.1M
11.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M
12.
Expression of vaccinia-related kinase 1 (VRK1) accelerates cell proliferation but overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma
Jing Liu, Yuchan Wang, Song He, Xiaohong Xu, Yuejiao Huang, Jie Tang, Yaxun Wu, Xiaobing Miao, Yunhua He, Qiru Wang, Li Liang, Chun Cheng
Hematology. 2016; 21(10): 603–612. Published online 2016 Jun 18. doi: 10.1080/10245332.2016.1147678
PMCID:
PMC9491125
AbstractArticlePDF–1.1M
13.
Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase
Alexandria C. Linville, Amber B. Rico, Helena Teague, Lucy E. Binsted, Geoffrey L. Smith, Jonas D. Albarnaz, Matthew S. Wiebe
J Virol. 2022 Jun; 96(11): e00398-22. Published online 2022 May 11. doi: 10.1128/jvi.00398-22
PMCID:
PMC9175622
AbstractArticlePDF–6.2M
14.
Inhibition of VRK1 suppresses proliferation and migration of vascular smooth muscle cells and intima hyperplasia after injury via mTORC1/β-catenin axis
Xiongshan Sun, Weiwei Zhao, Qiang Wang, Jiaqi Zhao, Dachun Yang, Yongjian Yang
BMB Rep. 2022 May 31; 55(5): 244–249. Published online 2022 May 31. doi: 10.5483/BMBRep.2022.55.5.019
PMCID:
PMC9152580
AbstractArticlePDF–3.6M
15.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
16.
Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity
Gabrielle R Budziszewski, Yani Zhao, Cathy J Spangler, Katarzyna M Kedziora, Michael R Williams, Dalal N Azzam, Aleksandra Skrajna, Yuka Koyama, Andrew P Cesmat, Holly C Simmons, Eyla C Arteaga, Joshua D Strauss, Dmitri Kireev, Robert K McGinty
Nucleic Acids Res. 2022 May 6; 50(8): 4355–4371. Published online 2022 Apr 7. doi: 10.1093/nar/gkac198
PMCID:
PMC9071384
AbstractArticlePDF–8.7M
17.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
18.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M
19.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
20.
HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation
Hye Guk Ryu, Youngseob Jung, Namgyu Lee, Ji-Young Seo, Sung Wook Kim, Kyung-Ha Lee, Do-Yeon Kim, Kyong-Tai Kim
Int J Mol Sci. 2021 Jun; 22(11): 5506. Published online 2021 May 23. doi: 10.3390/ijms22115506
PMCID:
PMC8197126
AbstractArticlePDF–2.9M

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